I
nte
rna
t
io
na
l J
o
urna
l o
f
Adv
a
nces in Applie
d Science
s
(
I
J
AAS)
Vo
l.
14
,
No
.
2
,
J
u
n
e
2
0
2
5
,
p
p
.
454
~
4
6
8
I
SS
N:
2252
-
8
8
1
4
,
DOI
:
1
0
.
1
1
5
9
1
/ijaas
.
v
14
.
i
2
.
pp
454
-
4
6
8
454
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m
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4
5
,
p
lac
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e
n
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in
o
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b
a
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e
a
lt
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c
a
re
sy
ste
m
s.
Early
d
e
tec
ti
o
n
a
n
d
a
c
c
u
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te
p
re
d
icti
o
n
o
f
d
iab
e
tes
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re
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e
n
ti
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l
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n
m
it
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ti
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g
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m
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ti
o
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s
a
n
d
re
d
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c
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g
m
o
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y
ra
tes
.
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we
v
e
r,
e
x
isti
n
g
d
iab
e
tes
p
re
d
ictio
n
fra
m
e
wo
rk
s
fa
c
e
c
h
a
ll
e
n
g
e
s,
i
n
c
lu
d
in
g
imb
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lan
c
e
d
d
a
tas
e
ts,
o
v
e
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ti
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g
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i
n
a
d
e
q
u
a
te
fe
a
tu
re
se
l
e
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ti
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n
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in
su
f
ficie
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t
h
y
p
e
rp
a
ra
m
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ter
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g
,
a
n
d
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k
o
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o
m
p
re
h
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e
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a
lu
a
ti
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c
s.
To
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d
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th
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c
h
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ll
e
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g
e
s,
th
e
p
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se
d
ra
n
d
o
m
fo
re
st
d
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tes
p
re
d
ictio
n
(
Ra
n
d
o
m
DIP)
fr
a
m
e
wo
rk
in
teg
ra
tes
a
d
v
a
n
c
e
d
tec
h
n
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e
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h
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y
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ra
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ter
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g
,
b
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lan
c
e
d
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g
,
a
n
d
o
p
ti
m
ize
d
fe
a
tu
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se
lec
ti
o
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u
sin
g
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ra
n
d
o
m
se
a
rc
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ro
ss
-
v
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li
d
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ti
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n
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Ra
n
d
o
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ize
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S
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a
rc
h
CV
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.
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is
fra
m
e
wo
rk
sig
n
ifi
c
a
n
tl
y
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e
s
p
re
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a
c
c
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ra
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y
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n
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n
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re
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re
li
a
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le
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n
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m
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c
h
iev
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s
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c
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ra
c
y
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tp
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r
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late
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y
7
.
2
3
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h
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re
a
u
n
d
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c
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rv
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(
AUC
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f
9
9
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6
%
,
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r
p
a
ss
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g
c
o
m
p
a
ra
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le
fra
m
e
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rk
s
b
y
7
.
3
2
%
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re
c
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ll
o
f
1
0
0
%
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e
d
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g
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e
ls
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y
9
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6
5
%
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re
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7
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%
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8
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n
d
o
u
t
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r
m
a
n
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o
f
6
.
6
9
%
.
Th
e
se
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e
tri
c
s
d
e
m
o
n
stra
te
Ra
n
d
o
m
DIP
'
s e
x
c
e
ll
e
n
t
c
a
p
a
c
it
y
to
id
e
n
ti
fy
d
iab
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tes
c
a
se
s wh
il
e
m
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imiz
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g
fa
lse
n
e
g
a
ti
v
e
s
(
FPs
)
a
n
d
p
ro
v
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d
in
g
re
li
a
b
le
p
re
d
icti
o
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s
fo
r
c
li
n
ica
l
u
se
.
F
u
tu
re
wo
r
k
will
f
o
c
u
s
o
n
i
n
teg
r
a
ti
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g
re
a
l
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ti
m
e
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li
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d
a
ta
a
n
d
e
x
p
a
n
d
in
g
th
e
fra
m
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wo
rk
to
a
c
c
o
m
m
o
d
a
te
m
u
lt
i
-
d
ise
a
se
p
re
d
icti
o
n
fo
r
b
r
o
a
d
e
r
h
e
a
lt
h
c
a
re
a
p
p
li
c
a
ti
o
n
s
.
K
ey
w
o
r
d
s
:
Diab
etes
Ho
s
p
ital
F
r
an
k
f
u
r
t
G
er
m
a
n
y
M
ac
h
in
e
lear
n
in
g
R
an
d
o
m
d
iab
etes p
r
e
d
ictio
n
R
an
d
o
m
f
o
r
est
T
h
is i
s
a
n
o
p
e
n
a
c
c
e
ss
a
rticle
u
n
d
e
r th
e
CC B
Y
-
SA
li
c
e
n
se
.
C
o
r
r
e
s
p
o
nd
ing
A
uth
o
r
:
T
s
h
iam
o
Sig
wele
Dep
ar
tm
en
t o
f
C
o
m
p
u
tin
g
an
d
I
n
f
o
r
m
atics
,
B
o
ts
wan
a
I
n
ter
n
atio
n
al
Un
iv
er
s
ity
o
f
Scien
ce
an
d
T
ec
h
n
o
lo
g
y
Plo
t 1
0
0
7
1
,
B
o
s
eja,
Palap
y
e,
B
o
ts
wan
a
E
m
ail:
s
ig
wele
t
@
b
iu
s
t.a
c.
b
w
1.
I
NT
RO
D
UCT
I
O
N
Diab
etes
m
ellitu
s
is
a
ch
r
o
n
ic
m
etab
o
lic
d
is
o
r
d
e
r
th
at
k
ee
p
s
th
e
b
lo
o
d
s
u
g
ar
le
v
el
h
ig
h
b
e
ca
u
s
e
th
e
b
o
d
y
eith
er
d
o
es
n
o
t
p
r
o
d
u
ce
en
o
u
g
h
in
s
u
lin
o
r
d
o
es
n
o
t
u
s
e
it
co
r
r
ec
tly
a
n
d
ca
n
ca
u
s
e
s
e
r
io
u
s
h
ar
m
to
m
a
n
y
o
th
er
o
r
g
a
n
s
,
s
u
ch
as th
e
h
ea
r
t,
ey
es,
n
er
v
es,
an
d
ev
en
d
ea
th
[
1
]
,
[
2
]
.
Diab
etes h
as two
m
ai
n
s
u
b
ty
p
es,
n
am
ely
ty
p
e
1
d
iab
etes
(
T
1
D)
an
d
ty
p
e
2
(
T
2
D)
,
ea
ch
r
eq
u
ir
in
g
p
e
r
s
o
n
alize
d
in
ter
v
en
tio
n
s
[
3
]
.
T
h
e
T
1
D
af
f
ec
ts
1
0
%
o
f
th
e
wo
r
ld
’
s
p
o
p
u
latio
n
wh
il
e
th
e
r
em
ain
in
g
9
0
%
is
af
f
ec
ted
b
y
T
2
D
[
4
]
,
[
5
]
.
I
t
is
v
er
y
cr
u
cial
to
ac
cu
r
ately
d
iag
n
o
s
e
th
ese
s
u
b
t
y
p
es
o
n
ti
m
e
to
av
o
id
c
o
m
p
licatio
n
s
o
r
d
ea
th
.
Stu
d
ies
in
d
icate
th
at
T
2
D
p
atien
ts
with
an
ea
r
ly
an
d
ac
cu
r
ate
d
iag
n
o
s
is
m
ay
av
o
i
d
8
0
%
o
f
co
m
p
licat
io
n
s
[
6
]
.
Diab
etes
h
as
af
f
ec
te
d
o
v
er
4
2
2
m
illi
o
n
p
eo
p
le
g
lo
b
ally
,
r
esu
ltin
g
in
a
b
o
u
t
1
.
5
m
illi
o
n
d
ea
th
s
y
ea
r
ly
[
7
]
.
Acc
o
r
d
i
n
g
to
esti
m
ates,
7
0
0
m
illi
o
n
p
e
o
p
le
Evaluation Warning : The document was created with Spire.PDF for Python.
I
n
t J
Ad
v
Ap
p
l Sci
I
SS
N:
2252
-
8
8
1
4
Op
timiz
in
g
d
ia
b
etes p
r
ed
ictio
n
u
s
in
g
ma
c
h
in
e
lea
r
n
in
g
:
a
r
a
n
d
o
m
fo
r
est a
p
p
r
o
a
ch
(
A
o
n
e
Ma
en
g
e)
455
will
b
e
af
f
ec
te
d
b
y
th
e
d
is
ea
s
e
in
2
0
4
5
wo
r
ld
wid
e
[
8
]
.
Acc
o
r
d
in
g
to
W
HO,
Af
r
ica
h
as
o
v
e
r
2
4
m
illi
o
n
ad
u
lts
liv
in
g
with
d
iab
etes,
an
d
th
is
n
u
m
b
er
is
esti
m
ated
to
in
cr
ea
s
e
b
y
1
2
9
%
to
r
ea
ch
5
5
m
illi
o
n
b
y
2
0
4
5
.
T
h
ese
h
ig
h
m
o
r
tality
n
u
m
b
er
s
in
d
i
ca
te
th
e
u
r
g
en
t
n
ee
d
f
o
r
ef
f
ec
tiv
e
d
iab
etes
p
r
ed
ictio
n
f
r
a
m
ewo
r
k
s
f
o
r
ea
r
ly
d
iag
n
o
s
is
an
d
p
r
e
v
en
tio
n
.
Sev
er
al
m
ac
h
i
n
e
lear
n
i
n
g
(
ML
)
f
r
am
ewo
r
k
s
h
av
e
b
ee
n
p
r
o
p
o
s
ed
f
o
r
d
ia
b
etes
p
r
ed
ictio
n
s
to
o
b
tain
h
id
d
en
i
n
s
ig
h
ts
f
r
o
m
b
io
m
ed
ical
d
atas
ets
to
m
in
im
ize
d
iab
etes
co
m
p
licatio
n
s
at
an
ea
r
ly
s
tag
e.
Nev
er
th
eless
,
th
er
e
ex
is
t
cr
itical
g
ap
s
in
cu
r
r
e
n
t w
o
r
k
s
th
at
n
ee
d
to
b
e
ad
d
r
ess
ed
.
R
esear
ch
g
ap
s
:
cu
r
r
en
t
ML
f
r
am
ewo
r
k
s
r
ely
o
n
a
m
in
im
a
l
s
et
o
f
f
ea
tu
r
es,
in
th
is
ca
s
e,
ju
s
t
f
iv
e,
wh
i
ch
m
ay
m
ak
e
it
m
o
r
e
d
if
f
icu
lt
f
o
r
th
e
m
o
d
el
to
ac
cu
r
at
ely
r
ep
r
esen
t
th
e
co
m
p
lex
ity
o
f
d
iab
etes
-
r
elate
d
f
ac
to
r
s
.
T
h
e
ex
cl
u
s
iv
e
r
elian
ce
o
n
life
s
ty
le
-
r
elate
d
f
ac
to
r
s
n
e
g
lectin
g
o
th
er
c
r
u
cial
co
n
t
r
ib
u
to
r
s
to
d
iab
etes c
an
p
o
ten
tially
co
m
p
r
o
m
is
e
th
e
f
r
am
ewo
r
k
'
s
co
m
p
r
eh
e
n
s
iv
en
e
s
s
.
T
h
e
u
s
e
o
f
f
em
ale
-
o
n
ly
d
atasets
in
m
o
d
el
tr
ain
in
g
in
tr
o
d
u
ce
s
g
e
n
d
er
b
ias,
p
o
ten
tially
co
m
p
r
o
m
is
in
g
th
e
m
o
d
el'
s
p
r
ed
ic
tiv
e
ac
cu
r
ac
y
a
n
d
g
en
er
aliza
b
ilit
y
to
u
n
d
er
r
ep
r
es
en
ted
g
r
o
u
p
s
,
s
u
ch
as
m
ales.
I
n
ad
d
itio
n
,
th
e
m
ajo
r
ity
o
f
f
r
a
m
ewo
r
k
s
ar
e
b
ased
s
o
lely
o
n
ac
cu
r
ac
y
m
etr
ics
o
v
er
lo
o
k
in
g
o
th
er
ess
en
tial
asp
e
cts
o
f
m
o
d
el
p
er
f
o
r
m
a
n
ce
.
C
u
r
r
en
t
m
o
d
els
ex
h
ib
it
s
u
b
o
p
tim
al
p
er
f
o
r
m
an
ce
,
ch
a
r
ac
ter
ized
b
y
lo
w
ac
cu
r
ac
y
an
d
h
ig
h
er
r
o
r
r
ates,
with
s
o
m
e
lack
in
g
d
o
c
u
m
en
ted
ac
cu
r
ac
y
m
etr
ics.
A
s
ig
n
if
ica
n
t
r
esear
ch
g
a
p
ex
is
ts
in
th
e
lack
o
f
em
b
ed
d
e
d
-
b
ased
f
ea
tu
r
e
s
elec
tio
n
m
eth
o
d
s
f
o
r
id
en
tify
i
n
g
cr
itical
d
ata
f
ea
tu
r
es,
as we
ll a
s
th
e
n
ee
d
f
o
r
f
in
e
-
tu
n
in
g
class
if
ier
s
to
en
h
an
ce
m
o
d
el
ac
cu
r
ac
y
.
T
h
ese
o
b
s
er
v
atio
n
s
em
p
h
asiz
e
th
e
im
p
o
r
tan
ce
o
f
ad
d
r
ess
in
g
th
ese
lim
itat
io
n
s
in
d
ev
el
o
p
in
g
an
d
ev
alu
atin
g
d
iab
etes
p
r
ed
ictio
n
f
r
am
ewo
r
k
s
to
en
h
an
ce
th
eir
co
m
p
r
eh
e
n
s
iv
en
ess
,
r
o
b
u
s
tn
ess
,
an
d
a
p
p
li
ca
b
ilit
y
.
T
h
u
s
,
it
is
ess
en
tial
to
d
ev
elo
p
a
f
r
a
m
ewo
r
k
th
at
ca
n
p
r
ed
ict
d
iab
etes
i
n
a
f
ea
s
ib
le,
p
r
ec
is
e,
an
d
co
s
t
-
ef
f
icien
t
m
a
n
n
er
.
Th
is
r
esear
ch
p
r
o
p
o
s
es
th
e
d
ev
elo
p
m
en
t
o
f
a
ML
f
r
am
ew
o
r
k
f
o
r
p
r
e
d
ictin
g
d
iab
etes
ac
cu
r
ately
lev
e
r
ag
in
g
r
an
d
o
m
f
o
r
est
alg
o
r
ith
m
s
to
b
r
id
g
e
g
a
p
s
in
e
x
is
tin
g
d
iab
ete
s
f
r
am
ewo
r
k
s
.
T
h
e
c
o
n
tr
ib
u
ti
o
n
s
o
f
t
h
is
r
esear
ch
wo
r
k
ar
e
as f
o
llo
ws,
i)
Gap
an
aly
s
is
:
id
en
tifie
d
k
ey
g
ap
s
in
ML
-
b
ased
d
iab
etes
p
r
e
d
ictio
n
f
r
a
m
ewo
r
k
s
in
cl
u
d
e
i
m
b
alan
ce
d
a
n
d
b
iased
d
atasets
,
in
s
u
f
f
icien
t
tr
ain
in
g
d
ata,
o
v
e
r
f
itti
n
g
,
r
ed
u
n
d
an
t
a
n
d
ir
r
elev
an
t
f
ea
tu
r
e
s
,
in
ad
eq
u
at
e
f
ea
tu
r
e
s
elec
tio
n
,
in
ad
e
q
u
at
e
m
o
d
el
tu
n
in
g
,
n
eg
lec
t
o
f
co
m
p
r
eh
en
s
iv
e
ev
alu
atio
n
m
etr
ics,
an
d
s
u
b
o
p
tim
al
p
er
f
o
r
m
a
n
ce
lik
e
p
r
ed
ictiv
e
ac
cu
r
ac
y
.
ii)
Fra
m
ewo
r
k
d
ev
elo
p
m
en
t:
d
ev
elo
p
ed
a
r
an
d
o
m
f
o
r
est
-
b
ased
ML
f
r
a
m
ewo
r
k
to
p
r
ed
ict
d
i
ab
etes
ca
lled
r
an
d
o
m
f
o
r
est d
ia
b
etes p
r
ed
ict
io
n
(
R
an
d
o
m
DI
P)
to
en
h
an
ce
p
r
ed
ictio
n
ac
c
u
r
ac
y
.
iii)
Data
s
et
m
an
ip
u
latio
n
:
ad
o
p
te
d
an
d
m
an
ip
u
late
d
th
e
Ho
s
p
ital
Fra
n
k
f
u
r
t
d
ataset
wh
ich
in
clu
d
ed
eig
h
t
in
d
ep
en
d
en
t v
ar
ia
b
les an
d
o
n
e
tar
g
et
v
ar
iab
le
t
o
s
u
it th
e
R
an
d
o
m
DI
P m
o
d
el.
iv
)
E
v
alu
atio
n
:
th
e
p
r
o
p
o
s
ed
R
an
d
o
m
DI
P
f
r
a
m
ewo
r
k
s
ig
n
if
i
ca
n
tly
o
u
tp
er
f
o
r
m
e
d
r
elate
d
wo
r
k
s
wh
en
ev
alu
ated
f
o
r
p
er
f
o
r
m
an
ce
i
n
ter
m
s
o
f
ac
cu
r
ac
y
,
a
r
ea
u
n
d
er
cu
r
v
e
(
AUC),
p
r
ec
is
io
n
,
r
ec
all,
an
d
F1
-
s
co
r
e.
T
h
e
r
est
o
f
th
is
a
r
ticle
is
s
tr
u
ctu
r
ed
as
f
o
llo
ws:
s
ec
tio
n
1
p
r
o
v
id
es
th
e
I
n
tr
o
d
u
ctio
n
o
f
th
e
r
esear
ch
f
o
llo
wed
b
y
s
ec
tio
n
2
wh
ic
h
d
escr
ib
es
th
e
p
r
o
p
o
s
ed
R
an
d
o
m
DI
P
f
r
a
m
ewo
r
k
.
T
h
e
s
tu
d
y
f
in
d
in
g
s
ar
e
p
r
esen
ted
an
d
an
aly
ze
d
in
s
ec
tio
n
3
wh
ile
s
ec
tio
n
4
b
r
i
n
g
s
th
e
s
tu
d
y
to
a
c
o
n
clu
s
io
n
.
L
iter
atu
r
e
r
ev
iew:
we
p
r
o
v
id
e
an
in
-
d
ep
th
g
ap
an
aly
s
is
b
y
co
n
d
u
ctin
g
a
r
ev
iew
o
f
th
e
ex
is
tin
g
liter
atu
r
e
f
r
o
m
2
0
2
4
u
p
to
5
y
ea
r
s
ag
o
o
n
d
iab
etes
p
r
e
d
ictio
n
,
h
ig
h
lig
h
tin
g
th
e
lim
itatio
n
s
an
d
r
esear
ch
g
ap
s
.
T
h
e
g
a
p
an
al
y
s
is
s
u
m
m
ar
y
is
t
h
at
cu
r
r
en
t
ML
f
r
am
ew
o
r
k
s
f
o
r
d
iab
etes p
r
ed
ictio
n
f
ac
e
s
ev
er
al
g
ap
s
,
i
n
clu
d
in
g
o
v
er
f
itti
n
g
,
f
ea
tu
r
e
r
ed
u
n
d
an
c
y
,
ir
r
elev
an
t
f
ea
tu
r
es,
im
b
ala
n
ce
d
an
d
b
iased
d
atasets
,
in
s
u
f
f
icien
t
d
ata,
n
eg
lect
o
f
p
er
f
o
r
m
an
ce
m
etr
ics,
s
u
b
o
p
tim
al
ac
cu
r
ac
y
,
an
d
in
ad
e
q
u
a
te
f
ea
tu
r
e
s
elec
tio
n
an
d
tu
n
in
g
.
T
h
e
f
o
llo
win
g
a
r
e
s
o
m
e
o
f
th
e
d
etailed
r
elate
d
f
r
am
ewo
r
k
s
with
th
eir
co
n
t
r
ib
u
t
io
n
s
an
d
g
ap
s
.
Atif
et
a
l.
[
4
]
p
er
f
o
r
m
s
a
n
an
al
y
s
is
o
f
ML
class
if
ier
s
f
o
r
p
r
e
d
ic
tin
g
d
iab
etes
m
ellitu
s
in
th
e
p
r
elim
in
ar
y
s
tag
e
b
u
t
th
e
r
e
is
p
o
o
r
ac
cu
r
ac
y
p
er
f
o
r
m
an
ce
.
Pra
n
to
et
a
l
.
[
5
]
an
aly
ze
d
d
iab
etes
p
r
e
d
ictio
n
u
s
in
g
th
e
r
an
d
o
m
f
o
r
est
al
g
o
r
ith
m
b
u
t
f
ac
e
d
s
ev
er
al
lim
itatio
n
s
.
T
h
e
r
elian
ce
o
n
o
n
ly
f
o
u
r
f
ea
tu
r
es
d
r
aws
atten
tio
n
to
lim
ited
an
d
in
ad
eq
u
ate
f
ea
t
u
r
e
s
elec
tio
n
,
r
ed
u
cin
g
th
e
m
o
d
el’
s
ab
ilit
y
to
r
ep
r
esen
t
th
e
co
m
p
lex
ity
o
f
d
iab
etes
-
r
ela
ted
f
ac
to
r
s
,
wh
ich
in
cr
ea
s
es
er
r
o
r
r
ates
an
d
h
in
d
er
s
p
r
ed
ictiv
e
ac
cu
r
ac
y
.
T
h
e
m
o
d
el’
s
r
elativ
ely
lo
w
ac
c
u
r
a
cy
(
7
8
%),
d
esp
ite
a
r
ec
all
o
f
8
9
%
an
d
F1
-
s
co
r
e
o
f
8
4
%,
e
m
p
h
asizes
s
u
b
o
p
ti
m
al
p
er
f
o
r
m
an
ce
a
n
d
o
v
er
f
itti
n
g
.
Ad
d
itio
n
ally
,
tr
ain
in
g
ex
cl
u
s
iv
ely
o
n
f
em
al
e
d
ata
in
tr
o
d
u
ce
s
g
en
d
er
b
ias
,
lim
itin
g
th
e
m
o
d
e
l’
s
g
en
e
r
al
izab
ilit
y
to
d
iv
er
s
e
p
o
p
u
latio
n
s
,
th
er
eb
y
p
r
o
d
u
ci
n
g
b
iased
p
r
e
d
ictio
n
s
an
d
o
v
e
r
s
im
p
lifie
d
d
ec
is
io
n
b
o
u
n
d
ar
ies
th
at
f
ail
to
ca
p
tu
r
e
r
ea
l
-
wo
r
ld
co
m
p
lex
ities
.
Ah
a
m
ed
et
a
l
.
[
8
]
em
p
lo
y
e
d
th
e
li
g
h
t
g
r
a
d
ien
t
b
o
o
s
tin
g
m
ac
h
i
n
e
(
L
GB
M)
alg
o
r
ith
m
f
o
r
d
iab
e
tes
p
r
e
d
ictio
n
,
ac
h
iev
in
g
an
ac
c
u
r
ac
y
o
f
9
5
.
2
0
%.
W
h
ile
th
e
s
tu
d
y
ex
p
lo
r
e
d
tr
an
s
f
o
r
m
e
r
-
b
ase
d
lear
n
in
g
f
o
r
d
ataset
en
h
a
n
ce
m
en
t,
it
r
elied
s
o
lely
o
n
ac
c
u
r
ac
y
f
o
r
ev
alu
atio
n
,
o
v
er
lo
o
k
in
g
o
th
er
cr
itical
p
er
f
o
r
m
an
ce
m
etr
ics
lik
e
p
r
ec
is
io
n
,
r
ec
all,
an
d
AUC.
A
lth
o
u
g
h
th
e
u
s
e
o
f
Nu
m
Py
,
Seab
o
r
n
,
an
d
MA
T
L
AB
f
o
r
an
aly
s
is
p
r
o
v
id
e
d
tr
an
s
p
ar
en
cy
,
th
e
ab
s
en
ce
o
f
f
u
r
th
er
f
i
n
e
-
tu
n
in
g
f
o
r
class
if
ier
s
r
ef
lects in
ad
eq
u
ate
m
o
d
el
o
p
tim
izatio
n
,
lim
itin
g
th
e
o
p
p
o
r
tu
n
ity
to
ac
h
ie
v
e
ev
en
b
etter
p
er
f
o
r
m
an
ce
.
T
h
e
s
tu
d
y
in
d
ic
ates th
e
im
p
o
r
tan
ce
o
f
u
tili
zin
g
d
iv
er
s
e
m
etr
ics
an
d
ad
d
itio
n
al
tu
n
i
n
g
to
im
p
r
o
v
e
m
o
d
el
ev
alu
atio
n
an
d
ac
cu
r
ac
y
.
J
o
s
h
i
an
d
Dh
ak
al
[
9
]
d
e
v
elo
p
e
d
a
d
iab
e
tes
p
r
ed
ictio
n
m
o
d
el
u
s
in
g
lo
g
is
tic
r
eg
r
ess
io
n
(
L
R
)
an
d
d
e
cisi
o
n
tr
ee
(
DT
)
b
u
t
en
co
u
n
ter
e
d
s
ig
n
if
ican
t
lim
itatio
n
s
.
T
h
e
u
s
e
o
f
o
n
ly
f
iv
e
f
ea
tu
r
es
in
d
icate
s
p
o
ten
tial
r
ed
u
n
d
a
n
cy
an
d
ir
r
elev
an
t
f
ea
t
u
r
es,
r
estrictin
g
th
e
m
o
d
el’
s
ca
p
ac
ity
t
o
c
ap
t
u
r
e
co
m
p
lex
d
iab
etes
p
r
e
d
icto
r
s
.
T
h
e
e
x
clu
s
iv
e
Evaluation Warning : The document was created with Spire.PDF for Python.
I
SS
N
:
2
2
5
2
-
8
8
1
4
I
n
t J Ad
v
Ap
p
l Sci
,
Vo
l.
14
,
No
.
2
,
J
u
n
e
2
0
2
5
:
4
5
4
-
468
456
r
elian
ce
o
n
d
ata
f
r
o
m
wo
m
en
(
Pima
I
n
d
ia
n
d
ataset)
in
tr
o
d
u
ce
s
b
ias
an
d
im
b
ala
n
ce
,
lim
iti
n
g
g
en
er
aliza
b
ilit
y
.
R
ep
o
r
tin
g
o
n
ly
ac
cu
r
ac
y
an
d
cr
o
s
s
-
v
alid
atio
n
er
r
o
r
r
ate
r
ef
lects
n
eg
lect
o
f
co
m
p
r
eh
en
s
iv
e
p
er
f
o
r
m
a
n
ce
m
etr
ics,
wh
ile
th
e
7
8
.
2
6
%
ac
cu
r
ac
y
an
d
2
1
.
7
4
%
er
r
o
r
s
u
g
g
est
s
u
b
o
p
tim
al
p
er
f
o
r
m
a
n
ce
an
d
p
o
ten
tial
o
v
er
f
itti
n
g
.
Un
s
p
ec
if
ied
to
o
ls
an
d
in
ad
eq
u
ate
m
o
d
el
d
etails
f
u
r
th
er
h
in
d
er
r
ep
licab
ilit
y
an
d
im
p
r
o
v
em
en
t
o
p
p
o
r
tu
n
ities
.
Af
tab
et
a
l
.
[
1
0
]
p
r
o
p
o
s
ed
a
f
u
s
ed
d
iab
etes
p
r
ed
ictio
n
m
o
d
el
co
m
b
in
in
g
n
aï
v
e
B
ay
es,
DT
,
an
d
ar
tific
ial
n
eu
r
al
n
etwo
r
k
alg
o
r
ith
m
s
,
ac
h
iev
in
g
h
ig
h
ac
cu
r
ac
y
(
9
5
.
2
0
%)
with
a
m
is
s
r
at
e
o
r
f
alse
n
e
g
ativ
e
(
FN
)
r
ate)
o
f
4
.
8
0
%.
Ho
wev
er
,
th
e
ev
alu
atio
n
m
et
r
ics
wer
e
lim
ited
to
ac
cu
r
ac
y
an
d
m
is
s
r
ate,
n
eg
lectin
g
co
m
p
r
eh
e
n
s
iv
e
p
e
r
f
o
r
m
an
ce
m
etr
ic
s
s
u
ch
as
r
ec
all,
p
r
ec
is
io
n
,
a
n
d
F1
-
s
co
r
e,
wh
ich
ar
e
e
s
s
en
tial
f
o
r
ass
ess
in
g
b
r
o
ad
e
r
m
o
d
el
p
er
f
o
r
m
a
n
ce
.
Fu
r
th
er
m
o
r
e
,
th
e
lack
o
f
d
eta
ils
ab
o
u
t
th
e
ML
to
o
ls
u
s
ed
r
ed
u
ce
s
r
ep
licab
ilit
y
an
d
in
ter
p
r
etab
ilit
y
.
T
h
ese
lim
itatio
n
s
,
d
esp
ite
p
r
o
m
is
in
g
r
es
u
lts
,
in
d
icate
th
e
n
e
ed
f
o
r
d
ee
p
er
ev
alu
atio
n
s
an
d
ex
p
licit
to
o
l
s
p
ec
if
icatio
n
s
to
en
s
u
r
e
th
e
r
o
b
u
s
tn
ess
o
f
th
e
m
o
d
el.
Sax
en
a
et
a
l
.
in
[
1
1
]
p
r
ed
icted
d
iab
etes
u
s
in
g
th
e
r
an
d
o
m
f
o
r
est
alg
o
r
ith
m
w
ith
f
ea
tu
r
e
s
elec
tio
n
m
eth
o
d
s
,
ac
h
iev
in
g
7
9
.
8
3
%
ac
c
u
r
ac
y
,
a
s
p
ec
if
icity
o
f
7
1
.
4
%,
a
s
en
s
itiv
ity
o
f
7
9
.
8
%,
an
d
an
AUC
o
f
8
3
.
6
%.
Ho
wev
er
,
th
e
m
o
d
el
was
tr
ain
ed
ex
clu
s
iv
ely
o
n
d
ata
f
r
o
m
p
r
e
g
n
an
t
wo
m
e
n
in
th
e
Pima
I
n
d
ian
s
d
ataset,
in
tr
o
d
u
cin
g
g
en
d
er
an
d
p
o
p
u
la
tio
n
b
ias
an
d
lim
itin
g
g
en
er
aliza
b
ilit
y
to
b
r
o
ad
e
r
d
em
o
g
r
ap
h
ics.
W
h
ile
p
er
f
o
r
m
an
ce
m
etr
ics
s
u
ch
as
s
en
s
itiv
ity
an
d
AUC
wer
e
p
r
o
m
is
in
g
,
t
h
e
r
elativ
ely
lo
w
ac
cu
r
ac
y
in
d
icate
s
s
u
b
o
p
tim
al
p
er
f
o
r
m
an
ce
.
Ad
d
itio
n
ally
,
t
h
e
u
s
e
o
f
W
ek
a
3
.
9
was
d
o
cu
m
en
ted
,
b
u
t
th
e
l
im
ited
d
ataset
d
iv
er
s
ity
r
estricts
th
e
m
o
d
el’
s
ab
ilit
y
to
m
ak
e
u
n
b
iased
an
d
r
ep
r
esen
tativ
e
p
r
e
d
ictio
n
s
.
Ag
liata
et
a
l
.
[
1
2
]
d
ev
elo
p
e
d
a
t
y
p
e
2
d
iab
etes
p
r
ed
ictio
n
m
o
d
el
u
s
in
g
th
e
Ad
am
alg
o
r
ith
m
,
ac
h
iev
in
g
an
ac
cu
r
ac
y
o
f
8
6
%
an
d
a
r
ec
eiv
er
o
p
e
r
atin
g
ch
a
r
ac
ter
is
tic
(
R
OC
)
AUC
o
f
9
3
.
4
%.
C
h
o
u
et
a
l.
[
1
3
]
p
r
o
p
o
s
es
a
f
r
am
ew
o
r
k
p
r
ed
ictin
g
th
e
o
n
s
et
o
f
d
ia
b
etes
with
ML
m
et
h
o
d
s
.
T
ah
a
an
d
Ma
leb
ar
y
[
1
4
]
p
r
o
p
o
s
es
a
h
y
b
r
id
m
eta
-
class
i
f
ier
o
f
f
u
zz
y
clu
s
ter
in
g
a
n
d
l
o
g
is
tic
r
eg
r
ess
io
n
f
o
r
d
iab
ete
s
p
r
ed
ictio
n
.
I
s
lam
et
a
l.
[
1
5
]
p
r
o
p
o
s
es
a
co
m
p
a
r
ativ
e
ap
p
r
o
ac
h
to
allev
iatin
g
th
e
p
r
ev
alen
ce
o
f
d
iab
etes
m
ellitu
s
u
s
in
g
ML
.
An
b
an
an
th
e
n
et
a
l.
[
1
6
]
p
r
o
p
o
s
ed
a
co
m
p
ar
ativ
e
p
er
f
o
r
m
a
n
c
e
an
aly
s
is
o
f
h
y
b
r
id
a
n
d
class
ical
ML
m
eth
o
d
s
in
p
r
ed
ictin
g
d
iab
etes.
Desp
ite
th
e
s
tr
o
n
g
R
OC
A
UC
,
th
e
e
v
alu
atio
n
r
elied
s
o
lely
o
n
ac
cu
r
ac
y
an
d
AUC,
n
eg
lectin
g
co
m
p
r
eh
en
s
iv
e
m
etr
ics
s
u
ch
as
s
en
s
itiv
ity
,
s
p
e
cif
icity
,
an
d
F1
-
s
co
r
e
.
T
h
e
m
o
d
el
u
tili
ze
d
th
r
ee
d
atasets
.
W
h
ile
th
e
d
ataset
d
i
v
er
s
ity
ad
d
s
v
alu
e,
th
e
lim
ited
ev
alu
atio
n
m
etr
ics
r
estrict
a
h
o
lis
tic
as
s
ess
m
en
t
o
f
th
e
m
o
d
el’
s
ef
f
ec
tiv
en
ess
.
T
h
is
ca
lls
f
o
r
b
r
o
ad
er
m
et
r
ics
to
p
r
o
v
i
d
e
m
o
r
e
r
o
b
u
s
t
an
d
i
n
ter
p
r
etab
le
m
o
d
el
in
s
ig
h
ts
.
2.
RE
S
E
ARCH
M
E
T
H
O
D
T
h
is
s
ec
tio
n
d
escr
ib
es
th
e
s
tep
s
ca
r
r
ied
o
u
t
in
th
e
d
ev
el
o
p
m
e
n
t
o
f
th
e
R
an
d
o
m
DI
P
m
o
d
el
to
ad
d
r
ess
th
e
id
en
tifie
d
g
ap
s
f
r
o
m
th
e
liter
atu
r
e
o
f
o
v
er
f
itti
n
g
,
f
ea
tu
r
e
is
s
u
es,
b
iased
d
atasets
,
in
s
u
f
f
icien
t
d
ata,
lim
ited
p
er
f
o
r
m
an
ce
m
etr
ics,
s
u
b
o
p
t
im
al
ac
cu
r
ac
y
,
in
a
d
eq
u
ate
f
ea
tu
r
e
s
elec
tio
n
,
an
d
tu
n
in
g
in
ML
m
o
d
els.
Ad
d
r
ess
in
g
t
h
ese
g
ap
s
will
b
e
ev
id
en
t
th
r
o
u
g
h
th
e
im
p
r
o
v
em
en
t
o
f
p
er
f
o
r
m
an
ce
m
etr
ic
s
s
u
ch
as
ac
cu
r
ac
y
,
AUC,
p
r
ec
is
io
n
,
r
ec
all,
a
n
d
F1
-
s
co
r
e
wh
ic
h
co
r
r
elate
with
t
h
e
g
ap
s
.
Fig
u
r
e
1
s
h
o
ws
th
e
ar
ch
itectu
r
e
f
o
r
t
h
e
p
r
o
p
o
s
ed
R
an
d
o
m
DI
P
f
r
a
m
ewo
r
k
f
o
r
d
iab
etes
p
r
ed
ict
io
n
.
T
h
e
s
t
ep
s
in
Fig
u
r
e
1
ar
e
ca
r
r
ied
o
u
t
to
s
y
s
tem
atica
lly
b
u
ild
,
tr
ain
,
an
d
ev
alu
ate
th
e
p
r
o
p
o
s
ed
R
an
d
o
m
DI
P
f
r
am
ewo
r
k
u
s
in
g
t
h
e
p
u
b
licly
av
ailab
le
Ho
s
p
ital
Fra
n
k
f
u
r
t
Ger
m
an
y
d
ataset.
T
h
e
p
r
o
p
o
s
ed
r
an
d
o
m
f
o
r
est
f
r
am
ewo
r
k
is
d
esig
n
ed
to
ac
h
iev
e
h
ig
h
p
r
ed
ictio
n
ac
c
u
r
ac
y
b
y
lev
e
r
ag
in
g
en
s
em
b
le
lear
n
in
g
tech
n
iq
u
es.
T
h
is
f
r
am
ewo
r
k
i
n
teg
r
ates
ad
v
a
n
ce
d
p
r
ep
r
o
ce
s
s
in
g
,
f
ea
tu
r
e
s
elec
tio
n
,
h
y
p
er
p
a
r
am
eter
t
u
n
in
g
,
an
d
r
ig
o
r
o
u
s
ev
alu
atio
n
m
etr
ics
t
o
en
s
u
r
e
r
o
b
u
s
t
an
d
r
eliab
le
p
r
ed
ictio
n
s
.
I
n
th
e
f
o
l
lo
win
g
,
we
p
r
o
v
id
e
a
d
etailed
ex
p
lan
atio
n
o
f
ea
ch
p
h
ase
o
f
th
e
m
eth
o
d
o
lo
g
y
,
ac
co
m
p
an
ied
b
y
r
elev
an
t e
q
u
a
tio
n
s
wh
er
e
n
ec
ess
ar
y
.
2
.
1
.
Da
t
a
s
et
a
cquis
it
io
n
Data
s
et
d
escr
ip
tio
n
an
d
q
u
ali
ty
:
th
e
d
ata
ac
q
u
is
itio
n
p
h
ase
is
cr
itical
in
d
ev
elo
p
in
g
th
e
p
r
o
p
o
s
ed
d
iab
etes
p
r
ed
ictio
n
f
r
am
ewo
r
k
.
T
h
is
p
h
ase
in
v
o
l
v
es
s
o
u
r
c
in
g
an
d
v
alid
atin
g
a
d
ataset
co
n
tain
in
g
f
ea
t
u
r
es
in
d
icativ
e
o
f
d
iab
etes.
T
h
e
d
a
taset
u
s
ed
in
th
is
f
r
am
ewo
r
k
i
s
th
e
Ho
s
p
ital
Fra
n
k
f
u
r
t
Ger
m
an
y
d
ataset,
wh
ich
is
p
u
b
licly
av
ailab
le
o
n
th
e
Kag
g
le
p
latf
o
r
m
.
T
h
e
H
o
s
p
ital
Fra
n
k
f
u
r
t
Ger
m
an
y
d
ataset
is
ch
o
s
en
f
o
r
its
co
m
p
r
eh
e
n
s
iv
e
f
ea
tu
r
e
s
et
th
at
ca
p
tu
r
es c
r
itical
d
iab
etes in
d
icato
r
s
,
m
ak
in
g
it h
ig
h
ly
r
elev
a
n
t to
th
e
p
r
ed
ictio
n
task
.
I
ts
lar
g
e
s
am
p
le
s
ize
e
n
h
an
ce
s
th
e
m
o
d
el'
s
ab
ilit
y
t
o
g
e
n
er
alize
ac
r
o
s
s
d
iv
er
s
e
p
atien
t
p
o
p
u
latio
n
s
,
en
s
u
r
in
g
r
o
b
u
s
t
an
d
r
eliab
l
e
p
r
ed
ictio
n
s
.
Ad
d
itio
n
ally
,
its
wid
esp
r
ea
d
ad
o
p
tio
n
i
n
p
r
ev
io
u
s
r
esear
ch
f
r
am
ewo
r
k
s
v
alid
ates
its
cr
ed
ib
ilit
y
an
d
u
tili
ty
in
d
iab
etes
-
r
elate
d
s
tu
d
ies,
r
ein
f
o
r
cin
g
its
s
u
itab
ilit
y
f
o
r
th
e
p
r
o
p
o
s
ed
f
r
am
ewo
r
k
[
3
]
,
[
1
0
]
,
[
1
3
]
,
[
1
4
]
.
Data
s
et
c
o
m
p
o
s
itio
n
:
th
e
d
ata
s
et
co
n
tain
s
2
,
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h
is
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alan
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is
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ib
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t
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r
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atio
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tr
ain
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els
wh
ile
m
in
im
izin
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b
ias
in
cla
s
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if
icatio
n
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lts
.
T
h
i
s
co
m
p
o
s
itio
n
m
ak
es
th
e
d
ataset
r
eliab
le
f
o
r
b
u
ild
in
g
acc
u
r
ate
an
d
b
alan
ce
d
p
r
ed
icti
o
n
alg
o
r
ith
m
s
.
Evaluation Warning : The document was created with Spire.PDF for Python.
I
n
t J
Ad
v
Ap
p
l Sci
I
SS
N:
2252
-
8
8
1
4
Op
timiz
in
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ia
b
etes p
r
ed
ictio
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s
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g
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c
h
in
e
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r
n
in
g
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r
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o
m
fo
r
est a
p
p
r
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ch
(
A
o
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Ma
en
g
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457
Fig
u
r
e
1
.
T
h
e
p
r
o
p
o
s
ed
R
an
d
o
m
DI
P
f
r
am
ewo
r
k
ar
ch
itectu
r
e
f
o
r
th
e
d
iab
etes p
r
e
d
ictio
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Data
s
et
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ep
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esen
tatio
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ip
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ch
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ac
ter
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tics
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e
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ataset
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wn
as in
p
u
t to
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e
f
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k
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u
r
e
1
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h
e
d
ata
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en
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ed
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els,
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d
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ll f
o
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en
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ity
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h
e
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ep
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ted
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.
=
{
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d
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e
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atien
t.
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h
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ich
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atien
t
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ar
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2000
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th
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m
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atien
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d
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ally
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=
9
is
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n
u
m
b
er
o
f
f
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tu
r
es
i
n
th
e
d
ataset.
T
h
ese
f
ea
tu
r
es
in
clu
d
e
g
lu
c
o
s
e
lev
els,
b
o
d
y
m
ass
in
d
ex
(
B
MI
)
,
in
s
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lin
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ag
e,
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d
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r
e,
s
k
in
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ick
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ess
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e
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n
a
n
cies,
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etes
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ed
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r
ee
f
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n
ctio
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d
o
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tco
m
e,
with
t
h
e
o
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tc
o
m
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a
r
iab
le
in
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wh
et
h
er
a
p
atien
t is d
iab
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o
r
n
o
t.
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ab
le
1
p
r
esen
ts
d
escr
ip
tiv
e
s
tatis
t
ics
o
f
th
e
d
ataset.
T
h
e
av
er
ag
e
g
lu
c
o
s
e
lev
el
is
1
2
1
.
1
8
m
g
/d
L
,
with
a
s
tan
d
ar
d
d
e
v
iatio
n
o
f
3
2
.
0
7
,
i
n
d
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g
s
ig
n
if
ica
n
t v
ar
iab
ilit
y
.
T
h
e
av
er
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g
e
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MI
is
3
2
.
1
9
,
s
u
g
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esti
n
g
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er
weig
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t
p
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latio
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e
a
m
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f
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0
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s
u
ch
as
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m
ax
im
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m
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o
f
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4
4
.
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t
ag
es
r
an
g
e
f
r
o
m
2
1
to
8
1
y
ea
r
s
,
with
a
m
ea
n
o
f
3
3
.
0
9
y
ea
r
s
.
T
h
e
d
ataset
is
b
alan
ce
d
,
with
3
4
%
d
iab
etic
ca
s
es,
en
s
u
r
in
g
a
r
elia
b
le
f
o
u
n
d
atio
n
f
o
r
p
r
ed
ictiv
e
a
n
aly
s
is
.
T
ab
le
1
.
T
h
e
d
escr
ip
tiv
e
s
tatis
tics
o
f
th
e
Ho
s
p
ital Fr
an
k
f
u
r
t
Ger
m
an
y
d
ataset
S
t
a
t
i
st
i
c
P
r
e
g
n
a
n
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y
G
l
u
c
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e
B
l
o
o
d
p
r
e
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S
k
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k
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n
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l
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n
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M
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t
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O
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C
o
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M
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Da
t
a
pre
-
pro
ce
s
s
ing
T
h
e
d
ata
p
r
e
-
p
r
o
ce
s
s
in
g
p
h
as
e
is
cr
u
cial
f
o
r
p
r
ep
a
r
in
g
th
e
d
ataset
f
o
r
t
h
e
r
a
n
d
o
m
f
o
r
est
m
o
d
el.
I
t
in
v
o
lv
es
a
s
er
ies
o
f
s
tep
s
to
e
n
s
u
r
e
th
at
th
e
d
ata
is
clea
n
,
r
elev
an
t,
an
d
r
ea
d
y
f
o
r
a
n
aly
s
is
.
T
h
ese
s
tep
s
h
elp
en
h
an
ce
th
e
q
u
ality
o
f
th
e
d
at
aset
an
d
,
i
n
tu
r
n
,
im
p
r
o
v
e
th
e
m
o
d
el’
s
p
er
f
o
r
m
a
n
ce
.
T
h
e
p
h
ase
in
clu
d
es
ex
p
lo
r
ato
r
y
d
ata
an
aly
s
is
(
E
DA)
,
wh
ich
h
elp
s
u
n
co
v
er
p
atter
n
s
an
d
r
elatio
n
s
h
ip
s
with
in
th
e
d
ata.
I
t
also
co
v
er
s
tech
n
i
q
u
es
lik
e
h
an
d
li
n
g
m
is
s
in
g
v
alu
es,
n
o
r
m
alizi
n
g
f
ea
t
u
r
es,
d
etec
tin
g
an
d
r
e
m
o
v
in
g
o
u
tlier
s
,
a
n
d
p
er
f
o
r
m
in
g
d
im
en
s
io
n
ality
r
ed
u
ctio
n
.
T
h
e
s
u
b
s
eq
u
e
n
t
s
u
b
s
ec
tio
n
s
ex
p
lain
t
h
ese
s
tep
s
in
d
et
ail,
elab
o
r
atin
g
o
n
ea
ch
p
r
o
ce
s
s
an
d
its
im
p
o
r
tan
c
e
in
en
s
u
r
in
g
th
e
d
ataset
is
o
p
t
im
al
f
o
r
tr
ain
in
g
.
Data
p
r
e
-
p
r
o
ce
s
s
in
g
p
h
ase
1
:
E
DA
is
p
e
r
f
o
r
m
e
d
to
s
u
m
m
ar
ize
an
d
v
is
u
alize
th
e
d
ataset,
p
r
o
v
id
i
n
g
in
s
ig
h
ts
in
to
its
s
tr
u
ctu
r
e
an
d
r
ev
ea
lin
g
p
atter
n
s
,
c
o
r
r
elatio
n
s
,
o
r
a
n
o
m
alies
[
1
5
]
.
Featu
r
e
d
is
tr
ib
u
tio
n
s
ar
e
Evaluation Warning : The document was created with Spire.PDF for Python.
I
SS
N
:
2
2
5
2
-
8
8
1
4
I
n
t J Ad
v
Ap
p
l Sci
,
Vo
l.
14
,
No
.
2
,
J
u
n
e
2
0
2
5
:
4
5
4
-
468
458
ex
am
in
ed
u
s
in
g
h
is
to
g
r
am
s
a
n
d
b
o
x
p
lo
ts
t
o
d
etec
t
s
k
ewn
ess
,
o
u
tlier
s
,
an
d
m
is
s
in
g
v
al
u
e
s
.
R
elatio
n
s
h
ip
s
b
etwe
en
f
ea
tu
r
es
ar
e
an
aly
ze
d
th
r
o
u
g
h
s
ca
tter
p
lo
ts
an
d
co
r
r
elatio
n
h
ea
tm
a
p
s
.
T
h
e
co
r
r
elatio
n
co
ef
f
icien
t
r
q
u
an
tifie
s
th
e
s
tr
en
g
th
o
f
r
el
atio
n
s
h
ip
s
.
Stro
n
g
co
r
r
elatio
n
s
(
r
>0
.
7
)
s
u
g
g
est
r
ed
u
n
d
a
n
c
y
,
g
u
id
in
g
f
ea
tu
r
e
s
elec
tio
n
f
o
r
d
iab
etes p
r
ed
icti
o
n
.
T
h
e
f
o
r
m
u
la
f
o
r
th
e
c
o
r
r
el
atio
n
co
ef
f
icien
t is
(
2
)
.
=
(
,
)
(
2
)
W
h
er
e
(
,
)
is
th
e
co
v
ar
ian
ce
b
et
wee
n
v
ar
iab
les
an
d
,
an
d
,
ar
e
th
eir
r
esp
ec
tiv
e
s
tan
d
ar
d
d
ev
iatio
n
s
.
I
n
th
e
Ho
s
p
ital
Fra
n
k
f
u
r
t
Ger
m
a
n
y
d
ia
b
etes
d
atase
t
as
s
h
o
wn
in
Fig
u
r
e
2
,
h
i
g
h
er
g
lu
c
o
s
e
lev
els
s
h
o
w
a
s
tr
o
n
g
c
o
r
r
elatio
n
with
d
iab
etes
p
r
esen
ce
(
r
>0
.
5
)
,
wh
ile
B
MI
an
d
a
g
e
h
a
v
e
wea
k
er
ass
o
ciatio
n
s
(
r
b
etwe
en
0
.
2
to
0
.
3
)
.
Hig
h
er
in
s
u
lin
lev
els
co
r
r
elate
s
tr
o
n
g
ly
with
g
l
u
co
s
e,
an
d
h
ig
h
er
s
k
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th
ick
n
ess
co
r
r
elate
s
with
in
s
u
lin
lev
els.
A
h
ig
h
er
B
MI
is
wea
k
ly
ass
o
c
iated
with
d
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etes
an
d
b
lo
o
d
p
r
ess
u
r
e,
an
d
o
ld
er
ag
e
s
h
o
ws a
wea
k
lin
k
to
d
iab
etes r
is
k
[
1
6
]
.
Fig
u
r
e
2
.
T
h
e
co
r
r
elatio
n
b
etw
ee
n
f
ea
tu
r
es
o
f
Ho
s
p
ital Fr
an
k
f
u
r
t
Ger
m
an
y
d
iab
etes d
ataset
Data
p
r
e
-
p
r
o
ce
s
s
in
g
p
h
ase
2
:
h
an
d
lin
g
m
is
s
in
g
v
alu
es
is
cr
itical
f
o
r
im
p
r
o
v
in
g
m
o
d
el
p
er
f
o
r
m
an
ce
an
d
en
s
u
r
i
n
g
ac
c
u
r
ate
p
r
ed
icti
o
n
s
.
Miss
in
g
v
alu
es
ar
e
im
p
u
t
ed
u
s
in
g
t
h
e
m
ed
ia
n
v
alu
e
o
f
th
e
co
r
r
esp
o
n
d
in
g
f
ea
tu
r
e
to
a
v
o
id
d
is
to
r
tio
n
f
r
o
m
o
u
tlier
s
[
1
5
]
.
T
h
e
im
p
u
tatio
n
f
o
r
m
u
la
is
(
3
)
.
=
{
(
{
1
,
2
,
…
,
}
)
if
is
mis
s
in
g
o
th
erw
is
e.
(
3
)
Her
e,
is
th
e
v
alu
e
o
f
th
e
-
th
f
ea
tu
r
e
f
o
r
th
e
-
th
s
am
p
le,
an
d
th
e
m
ed
ian
(
{
1
,
…
,
}
)
is
th
e
m
ed
ian
o
f
th
e
f
ea
tu
r
e
ac
r
o
s
s
all
s
am
p
les
.
T
h
is
m
eth
o
d
en
s
u
r
es
th
e
d
ataset
r
em
ain
s
r
o
b
u
s
t
with
o
u
t
in
tr
o
d
u
cin
g
b
iases
[
1
6
]
.
Data
p
r
e
-
p
r
o
ce
s
s
in
g
p
h
ase
3
:
f
ea
tu
r
e
n
o
r
m
aliza
tio
n
is
ap
p
lied
to
s
ca
le
f
ea
tu
r
es
to
a
co
m
p
ar
ab
le
r
an
g
e,
en
s
u
r
in
g
th
at
lar
g
e
-
m
a
g
n
itu
d
e
f
ea
tu
r
es
d
o
n
o
t
d
o
m
in
ate
m
o
d
el
tr
ain
i
n
g
.
T
h
e
z
-
s
co
r
e
n
o
r
m
aliza
tio
n
f
o
r
m
u
la
is
(
4
)
.
′
=
−
(
4
)
Evaluation Warning : The document was created with Spire.PDF for Python.
I
n
t J
Ad
v
Ap
p
l Sci
I
SS
N:
2252
-
8
8
1
4
Op
timiz
in
g
d
ia
b
etes p
r
ed
ictio
n
u
s
in
g
ma
c
h
in
e
lea
r
n
in
g
:
a
r
a
n
d
o
m
fo
r
est a
p
p
r
o
a
ch
(
A
o
n
e
Ma
en
g
e)
459
W
h
er
e
′
is
th
e
n
o
r
m
alize
d
v
al
u
e,
is
th
e
o
r
ig
i
n
al
v
alu
e,
is
th
e
m
ea
n
o
f
th
e
-
th
f
ea
tu
r
e,
a
n
d
is
its
s
tan
d
ar
d
d
ev
iati
o
n
.
T
h
is
s
tan
d
ar
d
izatio
n
ce
n
ter
s
ea
ch
f
ea
t
u
r
e
ar
o
u
n
d
a
m
e
an
o
f
0
with
a
u
n
it
s
tan
d
ar
d
d
ev
iatio
n
,
e
n
h
an
cin
g
m
o
d
el
co
n
v
er
g
e
n
ce
an
d
im
p
r
o
v
in
g
p
er
f
o
r
m
an
ce
[
1
6
]
.
Data
p
r
e
-
p
r
o
ce
s
s
in
g
p
h
ase
4
:
o
u
tlier
d
etec
tio
n
a
n
d
r
em
o
v
al
,
th
e
o
u
tlier
s
s
h
o
wn
in
Fig
u
r
e
3
ar
e
d
at
a
p
o
in
ts
th
at
d
ev
iate
s
ig
n
i
f
ican
tly
f
r
o
m
t
h
e
r
est
o
f
th
e
d
atas
et,
o
f
ten
ca
u
s
ed
b
y
er
r
o
r
s
in
d
ata
co
llectio
n
o
r
m
ea
s
u
r
em
en
t.
T
h
ese
o
u
tlier
s
ca
n
d
is
to
r
t
p
r
ed
ictio
n
s
an
d
le
ad
to
in
ac
cu
r
ate
m
o
d
el
p
er
f
o
r
m
an
ce
.
I
n
d
iab
etes
p
r
ed
ictio
n
,
ab
n
o
r
m
al
v
alu
es,
s
u
ch
as
ex
tr
em
e
g
lu
c
o
s
e
lev
els,
ca
n
s
k
ew
r
esu
lts
,
m
ak
in
g
th
e
m
o
d
el
u
n
r
eliab
le
.
T
o
ad
d
r
ess
th
is
,
th
e
in
ter
q
u
ar
tile
r
an
g
e
(
I
QR
)
m
eth
o
d
is
u
s
ed
to
d
etec
t
an
d
r
em
o
v
e
o
u
t
lier
s
.
T
h
e
I
QR
an
d
o
u
tlier
in
eq
u
ality
ar
e
ca
lcu
late
d
as
(
5
)
a
n
d
(
6
).
=
3
−
1
(
5
)
<
1
−
1
.
5
⋅
or
>
3
+
1
.
5
⋅
(
6
)
W
h
er
e
1
an
d
3
r
ep
r
esen
t
th
e
2
5
th
an
d
7
5
th
p
er
ce
n
tiles
o
f
t
h
e
d
ataset,
r
esp
ec
tiv
ely
.
An
y
d
ata
p
o
in
t
f
allin
g
o
u
ts
id
e
th
e
r
an
g
e
in
(
6
)
is
co
n
s
id
er
ed
an
o
u
tlier
a
n
d
r
em
o
v
ed
.
T
h
is
p
r
o
ce
s
s
en
s
u
r
es
clea
n
er
,
m
o
r
e
r
eliab
le
d
ata,
im
p
r
o
v
in
g
m
o
d
el
g
en
er
aliza
tio
n
an
d
p
r
e
d
ictio
n
ac
cu
r
ac
y
.
R
em
o
v
in
g
o
u
tlier
s
as
s
h
o
wn
in
Fig
u
r
e
4
h
elp
s
th
e
m
o
d
el
av
o
id
in
s
tab
ilit
y
,
o
v
e
r
f
itti
n
g
,
an
d
p
o
o
r
p
er
f
o
r
m
an
ce
,
lead
in
g
to
b
etter
d
ec
is
io
n
-
m
ak
in
g
[
1
6
]
-
[
1
8
]
.
Fig
u
r
e
3
.
Data
p
r
e
-
pr
o
ce
s
s
in
g
p
h
ase
4
: o
u
tlier
d
etec
tio
n
o
f
e
ac
h
f
ea
tu
r
e
Fig
u
r
e
4
.
Data
p
r
e
-
p
r
o
ce
s
s
in
g
p
h
ase
4
: o
u
tlier
s
r
em
o
v
al
d
ata
p
o
in
ts
d
is
tr
ib
u
tio
n
Evaluation Warning : The document was created with Spire.PDF for Python.
I
SS
N
:
2
2
5
2
-
8
8
1
4
I
n
t J Ad
v
Ap
p
l Sci
,
Vo
l.
14
,
No
.
2
,
J
u
n
e
2
0
2
5
:
4
5
4
-
468
460
Data
p
r
e
-
p
r
o
ce
s
s
in
g
p
h
ase
5
:
d
im
en
s
io
n
ality
r
ed
u
ctio
n
,
to
r
ed
u
ce
co
m
p
u
tatio
n
al
c
o
m
p
l
ex
ity
an
d
m
itig
ate
o
v
er
f
itti
n
g
,
p
r
in
cip
al
co
m
p
o
n
en
t
an
aly
s
is
(
PC
A)
ca
n
b
e
a
p
p
lied
.
PC
A
tr
an
s
f
o
r
m
s
th
e
o
r
ig
i
n
al
d
ata
m
atr
ix
in
to
a
lo
wer
-
d
im
en
s
io
n
al
s
p
ac
e
wh
ile
r
etain
in
g
m
o
s
t
o
f
th
e
d
ata
v
ar
ia
n
ce
=
,
wh
er
e
is
th
e
o
r
ig
in
al
d
ata
m
atr
ix
,
is
th
e
m
atr
ix
o
f
eig
en
v
ec
to
r
s
(
p
r
in
c
ip
al
co
m
p
o
n
en
ts
)
d
er
iv
e
d
f
r
o
m
th
e
co
v
ar
ian
ce
m
atr
ix
o
f
,
an
d
is
th
e
tr
an
s
f
o
r
m
ed
f
ea
t
u
r
e
s
p
ac
e.
Fo
r
in
s
tan
c
e,
h
ig
h
-
d
im
e
n
s
io
n
al
f
ea
t
u
r
es
li
k
e
B
MI
,
in
s
u
lin
lev
els,
an
d
g
lu
co
s
e
m
ea
s
u
r
e
m
en
ts
ar
e
co
n
d
en
s
ed
in
to
f
e
wer
d
im
en
s
io
n
s
wh
ile
p
r
eser
v
in
g
cr
itical
p
atter
n
s
in
f
lu
en
cin
g
d
iab
etes
p
r
ed
icti
o
n
[
1
6
]
.
T
h
is
r
e
d
u
ce
s
co
m
p
u
tatio
n
al
co
m
p
lex
ity
a
n
d
m
i
tig
ates
th
e
r
is
k
o
f
o
v
er
f
itti
n
g
.
2
.
3
.
M
o
del t
ra
ini
ng
Mo
d
el
tr
ain
in
g
p
h
ase
1
:
d
ata
s
p
litt
in
g
,
wh
en
we
tr
ain
th
e
r
an
d
o
m
f
o
r
est
m
o
d
el,
we
ar
e
teac
h
in
g
it
to
p
r
ed
ict
th
e
o
u
tco
m
e
(
wh
et
h
e
r
a
p
er
s
o
n
h
as
d
iab
etes
o
r
n
o
t)
b
ased
o
n
p
atter
n
s
in
th
e
tr
ain
in
g
d
ata.
T
h
is
tr
ain
in
g
p
r
o
ce
s
s
allo
ws
th
e
m
o
d
el
to
lear
n
f
r
o
m
t
h
e
f
ea
t
u
r
es
(
s
u
ch
as
g
lu
co
s
e
lev
els
an
d
B
MI
)
an
d
m
a
k
e
p
r
ed
ictio
n
s
f
o
r
n
ew,
u
n
s
ee
n
d
ata.
On
ce
t
h
e
d
ata
h
as
b
ee
n
p
r
e
-
p
r
o
ce
s
s
ed
a
n
d
clea
n
ed
,
it
i
s
s
p
lit
in
to
tr
ain
i
n
g
an
d
test
in
g
s
ets
u
s
in
g
an
8
0
:2
0
r
atio
.
T
h
e
tr
ain
in
g
s
et
(
8
0
%)
is
u
s
ed
to
tr
ain
th
e
ML
m
o
d
el,
wh
ile
th
e
test
in
g
s
et
(
2
0
%)
is
u
s
ed
to
ev
alu
ate
its
p
er
f
o
r
m
a
n
ce
.
T
h
is
en
s
u
r
e
s
th
e
m
o
d
el
ca
n
g
en
er
alize
to
n
ew,
u
n
s
ee
n
d
ata.
T
o
o
ls
lik
e
s
cik
it
-
lear
n
'
s
tr
ain
_
test
_
s
p
lit
f
u
n
ctio
n
a
r
e
u
s
ed
to
r
an
d
o
m
ly
d
iv
id
e
th
e
d
at
aset,
m
ain
tain
in
g
a
b
alan
ce
d
r
ep
r
esen
tatio
n
o
f
d
iab
etic
an
d
n
o
n
-
d
iab
etic
ca
s
e
s
in
b
o
th
s
u
b
s
ets,
wh
ich
h
el
p
s
im
p
r
o
v
e
m
o
d
el
ac
cu
r
ac
y
a
n
d
r
eliab
ilit
y
.
T
h
e
tr
ain
in
g
s
et
is
u
s
ed
t
o
tr
ain
th
e
r
an
d
o
m
f
o
r
est
m
o
d
el,
a
ML
alg
o
r
ith
m
d
esig
n
ed
to
p
r
ed
ict
d
iab
etes
o
u
tco
m
es.
Du
r
in
g
tr
ain
in
g
,
th
e
m
o
d
el
l
ea
r
n
s
th
e
p
atter
n
s
an
d
r
elatio
n
s
h
ip
s
b
etwe
en
th
e
in
p
u
t
f
ea
tu
r
es
(
s
u
ch
as
g
lu
co
s
e
lev
els,
in
s
u
lin
,
an
d
B
MI
)
an
d
th
e
tar
g
et
v
ar
iab
le
(
d
ia
b
etes
s
tatu
s
)
.
Af
ter
tr
ain
in
g
,
th
e
m
o
d
el
is
ev
alu
ate
d
u
s
in
g
th
e
test
in
g
s
et,
wh
ich
co
n
tain
s
d
ata
it
h
as
n
ev
er
s
ee
n
b
ef
o
r
e.
E
v
alu
atio
n
m
etr
ics
s
u
ch
as
ac
cu
r
ac
y
,
p
r
ec
is
io
n
,
r
ec
all,
an
d
F1
-
s
co
r
e
ar
e
ca
lcu
lated
to
ass
es
s
th
e
m
o
d
el'
s
p
r
ed
ictiv
e
p
er
f
o
r
m
an
ce
.
A
d
d
itio
n
ally
,
r
e
s
u
lts
f
r
o
m
K
-
f
o
l
d
cr
o
s
s
-
v
alid
atio
n
ar
e
u
s
ed
to
f
in
e
-
tu
n
e
h
y
p
er
p
ar
am
eter
s
s
u
c
h
as
tr
ee
d
ep
th
an
d
n
u
m
b
e
r
o
f
esti
m
ato
r
s
to
im
p
r
o
v
e
th
e
m
o
d
el’
s
g
en
er
aliza
tio
n
a
n
d
a
cc
u
r
ac
y
,
en
s
u
r
in
g
it
p
er
f
o
r
m
s
o
p
tim
ally
o
n
n
ew,
u
n
s
ee
n
d
ata
.
T
h
e
f
o
llo
win
g
ar
e
ar
e
th
e
d
etailed
p
h
ases
f
o
r
m
o
d
el
tr
ain
in
g
o
f
R
an
d
o
m
DI
P.
Mo
d
el
tr
ain
in
g
p
h
ase
2
:
alg
o
r
ith
m
f
o
r
cr
ea
tio
n
o
f
r
a
n
d
o
m
f
o
r
est
,
t
h
e
r
a
n
d
o
m
f
o
r
est
alg
o
r
ith
m
,
as
o
u
tlin
ed
in
Alg
o
r
it
h
m
1
,
is
em
p
lo
y
ed
to
c
o
n
s
tr
u
ct
a
r
o
b
u
s
t
d
i
ab
etes
p
r
ed
ictio
n
m
o
d
el.
T
h
is
en
s
em
b
le
lear
n
in
g
ap
p
r
o
ac
h
cr
ea
tes
m
u
ltip
le
DT
s
,
ea
ch
tr
ain
ed
o
n
a
r
an
d
o
m
s
u
b
s
et
o
f
th
e
d
iab
etes
d
ataset
u
s
in
g
th
e
b
o
o
ts
tr
ap
s
am
p
lin
g
m
eth
o
d
[
3
]
,
[
1
9
]
.
T
h
e
m
o
d
el
p
r
ed
icts
d
iab
etes
o
u
tco
m
es
b
y
ag
g
r
eg
atin
g
p
r
ed
i
ctio
n
s
f
r
o
m
all
th
e
in
d
iv
id
u
al
DT
s
.
T
h
e
p
r
e
d
ictio
n
p
r
o
ce
s
s
f
o
r
th
e
r
a
n
d
o
m
f
o
r
es
t m
o
d
el
is
r
ep
r
esen
ted
m
ath
em
atica
lly
as
(
7
)
.
=
(
1
(
)
,
2
(
)
,
…
,
(
)
)
(
7
)
W
h
er
e
is
th
e
p
r
ed
icted
d
iab
etes
clas
s
if
icatio
n
r
esu
lt
f
o
r
th
e
in
p
u
t
f
ea
tu
r
es
,
(
)
d
en
o
tes
th
e
p
r
ed
ictio
n
f
r
o
m
t
h
e
-
th
DT
,
a
n
d
is
th
e
to
tal
n
u
m
b
er
o
f
DT
s
i
n
t
h
e
en
s
em
b
le.
T
h
e
m
o
d
e
f
u
n
ctio
n
ag
g
r
eg
ates
p
r
ed
ictio
n
s
b
y
s
elec
tin
g
th
e
m
o
s
t
f
r
eq
u
en
tly
o
cc
u
r
r
in
g
class
lab
el
ac
r
o
s
s
all
tr
ee
s
.
T
h
is
m
ajo
r
ity
v
o
tin
g
m
ec
h
an
is
m
en
s
u
r
es
t
h
at
th
e
m
o
d
el
r
e
d
u
ce
s
o
v
er
f
itti
n
g
co
m
p
ar
ed
to
in
d
iv
i
d
u
al
DT
s
[
2
0
]
,
[
2
1
]
.
B
y
co
m
b
in
in
g
th
e
s
tr
en
g
th
s
o
f
m
u
ltip
le
tr
ee
s
,
r
an
d
o
m
f
o
r
est
en
h
an
ce
s
p
r
e
d
ictiv
e
ac
cu
r
ac
y
an
d
g
e
n
e
r
aliza
tio
n
,
m
ak
in
g
it
an
ef
f
ec
tiv
e
to
o
l
f
o
r
d
iab
etes
cl
ass
if
icatio
n
.
T
h
e
m
o
d
e
f
u
n
ctio
n
a
g
g
r
eg
ates
p
r
ed
ictio
n
s
b
y
s
elec
tin
g
th
e
m
o
s
t
f
r
eq
u
e
n
tly
o
cc
u
r
r
in
g
class
lab
el
ac
r
o
s
s
all
tr
ee
s
.
Alg
o
r
ith
m
1
.
Alg
o
r
ith
m
f
o
r
cr
ea
tio
n
o
f
r
an
d
o
m
f
o
r
est
I
n
p
u
t:
no
.
o
f
tr
ee
s
(
T
)
,
no
.
o
f
f
ea
tu
r
es (
m
)
,
tr
ain
i
n
g
d
ataset
(
,
)
,
b
o
o
ts
tr
ap
s
am
p
lin
g
m
eth
o
d
.
Ou
tp
u
t: γ
:
f
in
al
p
r
ed
ictio
n
(
d
ia
b
etes c
lass
if
icatio
n
r
esu
lt).
1.
Set
no
.
o
f
tr
ee
s
:
d
ef
in
e
th
e
t
o
tal
n
u
m
b
er
o
f
DT
s
f
o
r
d
iab
etes
p
r
ed
ictio
n
as T
.
2.
Select
n
o
.
o
f
f
ea
tu
r
es: s
p
ec
if
y
,
th
e
n
u
m
b
er
o
f
in
p
u
t f
ea
tu
r
es u
s
ed
b
y
ea
c
h
tr
ee
to
s
p
lit n
o
d
e
s
.
3.
I
n
itialize
co
u
n
ter
: set
tr
ee
co
u
n
ter
i
←
1.
4.
wh
ile
i ≤
T
d
o
5.
R
an
d
o
m
ly
s
am
p
le
d
ata
with
r
e
p
lace
m
en
t f
r
o
m
th
e
d
iab
etes tr
ain
in
g
d
ataset
.
6.
R
an
d
o
m
ly
s
elec
t F
m
,
th
e
s
u
b
s
et
o
f
f
ea
tu
r
es f
o
r
th
e
ℎ
tr
ee
f
r
o
m
th
e
to
tal
f
ea
tu
r
e
s
et.
7.
T
r
ain
th
e
ℎ
DT
u
s
in
g
th
e
s
am
p
l
ed
d
ataset
an
d
s
elec
ted
f
ea
tu
r
e
s
u
b
s
et.
8.
I
n
cr
em
en
t tr
ee
co
u
n
ter
: i
←
i
+
1.
9.
en
d
10.
Fin
al
p
r
ed
ictio
n
: d
eter
m
in
e
d
i
ab
etes o
u
tco
m
e
u
s
in
g
m
ajo
r
ity
v
o
tin
g
ac
r
o
s
s
T
tr
ee
s
f
o
r
n
ew
in
p
u
ts
Mo
d
el
tr
ain
in
g
p
h
ase
3
:
K
-
f
o
l
d
cr
o
s
s
-
v
alid
atio
n
en
h
an
ce
s
th
e
r
o
b
u
s
tn
ess
an
d
g
e
n
er
aliza
b
il
ity
o
f
t
h
e
d
iab
etes
p
r
ed
ictio
n
m
o
d
el
b
y
d
iv
id
in
g
th
e
d
ataset
in
to
K
eq
u
al
-
s
ized
s
u
b
s
ets
o
r
f
o
ld
s
.
T
h
e
m
o
d
el
is
tr
ain
ed
K
Evaluation Warning : The document was created with Spire.PDF for Python.
I
n
t J
Ad
v
Ap
p
l Sci
I
SS
N:
2252
-
8
8
1
4
Op
timiz
in
g
d
ia
b
etes p
r
ed
ictio
n
u
s
in
g
ma
c
h
in
e
lea
r
n
in
g
:
a
r
a
n
d
o
m
fo
r
est a
p
p
r
o
a
ch
(
A
o
n
e
Ma
en
g
e)
461
tim
es,
u
s
in
g
K
-
1
f
o
ld
s
f
o
r
t
r
a
in
in
g
an
d
th
e
r
e
m
ain
in
g
f
o
ld
f
o
r
test
in
g
.
T
h
is
m
eth
o
d
en
s
u
r
es
a
m
o
r
e
r
eliab
le
ev
alu
atio
n
o
f
th
e
m
o
d
el'
s
p
er
f
o
r
m
an
ce
an
d
m
itig
ates
o
v
er
f
itti
n
g
.
T
h
e
p
er
f
o
r
m
a
n
ce
m
etr
ic
f
o
r
ea
c
h
f
o
ld
(
)
is
co
m
p
u
ted
,
a
n
d
t
h
e
a
v
er
ag
e
p
e
r
f
o
r
m
a
n
ce
(
)
is
ca
lcu
lated
ac
r
o
s
s
all
K
f
o
ld
s
.
T
h
is
ap
p
r
o
ac
h
en
s
u
r
es
t
h
at
ea
ch
s
u
b
s
et
o
f
th
e
d
iab
etes
d
ataset
is
u
s
ed
f
o
r
test
in
g
,
o
f
f
e
r
in
g
a
co
m
p
r
e
h
en
s
iv
e
ass
ess
m
en
t
o
f
th
e
m
o
d
el'
s
ab
ilit
y
to
p
r
ed
ict
d
iab
etes a
cc
u
r
ately
.
=
1
∑
=
1
(
8
)
W
h
er
e
r
ep
r
esen
ts
th
e
av
er
a
g
e
p
er
f
o
r
m
an
ce
o
f
th
e
m
o
d
el
ac
r
o
s
s
all
f
o
ld
s
,
p
r
o
v
id
i
n
g
an
o
v
e
r
all
ev
alu
atio
n
o
f
th
e
m
o
d
el'
s
ab
ilit
y
to
p
r
ed
ict
d
iab
etes.
K
d
en
o
tes
th
e
to
tal
n
u
m
b
er
o
f
f
o
ld
s
o
r
s
u
b
s
ets
o
f
th
e
d
iv
id
ed
d
ataset
.
r
ef
er
s
to
th
e
p
er
f
o
r
m
an
ce
m
etr
ic
(
e.
g
.
,
ac
c
u
r
ac
y
,
p
r
ec
is
io
n
,
an
d
r
ec
a
ll)
o
b
tain
ed
f
r
o
m
th
e
ℎ
f
o
ld
d
u
r
in
g
test
in
g
,
wh
ic
h
r
ef
lects
h
o
w
well
th
e
m
o
d
el
p
e
r
f
o
r
m
s
o
n
th
at
s
p
ec
if
ic
s
u
b
s
et.
B
y
av
er
ag
in
g
v
alu
es a
cr
o
s
s
all
f
o
ld
s
,
th
e
m
o
d
el’
s
g
en
er
aliza
b
ilit
y
is
ass
ess
ed
,
en
s
u
r
in
g
it p
er
f
o
r
m
s
well
o
n
u
n
s
ee
n
d
ata.
Mo
d
el
tr
ain
in
g
p
h
ase
4
:
h
y
p
er
p
ar
am
eter
o
p
tim
izatio
n
,
i
n
th
is
s
ec
tio
n
,
th
e
tr
ain
in
g
p
r
o
c
ess
o
f
th
e
r
an
d
o
m
f
o
r
est
m
o
d
el
is
in
teg
r
ated
with
h
y
p
er
p
ar
am
eter
t
u
n
in
g
to
o
p
tim
ize
its
p
er
f
o
r
m
an
ce
f
o
r
d
iab
etes
p
r
ed
ictio
n
,
as
s
h
o
wn
in
Alg
o
r
ith
m
2
.
R
an
d
o
m
s
ea
r
ch
cr
o
s
s
-
v
alid
atio
n
(
R
an
d
o
m
ize
d
Sear
ch
C
V
)
is
ch
o
s
en
as
an
ef
f
ec
tiv
e
tech
n
iq
u
e
f
o
r
f
in
d
in
g
th
e
b
est
co
m
b
in
atio
n
o
f
h
y
p
er
p
a
r
am
eter
s
f
o
r
th
e
r
an
d
o
m
f
o
r
est
m
o
d
el,
o
p
tim
izin
g
it
f
o
r
b
etter
p
r
ed
ict
iv
e
p
er
f
o
r
m
a
n
ce
.
I
t
h
elp
s
in
tu
n
in
g
k
ey
p
ar
a
m
eter
s
s
u
ch
as
t
h
e
n
u
m
b
er
o
f
tr
ee
s
(
T
)
,
m
a
x
im
u
m
d
ep
t
h
(
m
a
x
_
d
ep
th
)
,
t
h
e
n
u
m
b
er
o
f
f
ea
tu
r
e
s
u
s
ed
in
tr
ee
s
p
litt
in
g
(
m
)
,
m
in
im
u
m
s
am
p
les
r
eq
u
ir
ed
to
s
p
lit an
in
ter
n
al
n
o
d
e
(
m
in
_
s
am
p
les_
s
p
lit),
an
d
t
h
e
m
in
im
u
m
s
am
p
les r
eq
u
ir
e
d
to
b
e
at
a
leaf
n
o
d
e
(
m
in
_
s
am
p
les_
leaf
)
.
T
h
is
tu
n
in
g
d
ir
ec
tly
in
f
lu
en
ce
s
t
h
e
m
o
d
el'
s
ac
cu
r
ac
y
an
d
a
b
ilit
y
to
g
en
e
r
alize
.
T
h
e
m
o
d
el
tr
ai
n
in
g
co
n
s
is
ts
o
f
f
itti
n
g
th
e
r
an
d
o
m
f
o
r
est
alg
o
r
i
th
m
u
s
in
g
th
e
tr
ain
in
g
d
ata
u
s
in
g
Alg
o
r
ith
m
1
,
wh
ile
s
im
u
ltan
eo
u
s
ly
f
in
e
-
tu
n
in
g
t
h
e
h
y
p
er
p
ar
am
eter
s
u
s
in
g
R
an
d
o
m
ized
Sear
ch
C
V
.
T
h
e
o
b
jectiv
e
is
t
o
m
ax
im
ize
th
e
p
e
r
f
o
r
m
an
ce
m
etr
ic
(
s
u
ch
as
ac
cu
r
ac
y
,
p
r
ec
is
io
n
,
o
r
r
ec
all)
b
y
a
d
ju
s
tin
g
t
h
ese
p
ar
am
eter
s
,
wh
ich
en
h
an
ce
s
th
e
r
an
d
o
m
f
o
r
est
m
o
d
el'
s
ab
ilit
y
to
p
r
ed
ict
d
iab
etes.
T
h
e
o
p
tim
izatio
n
p
r
o
b
lem
is
ex
p
r
ess
ed
as
(
9
)
.
∗
=
∈
(
(
tr
ain
,
)
,
tr
ain
)
(
9
)
W
h
er
e
Θ
r
ep
r
esen
ts
th
e
s
et
o
f
h
y
p
er
p
ar
am
eter
s
,
wh
ich
i
n
clu
d
es
th
e
n
u
m
b
e
r
o
f
t
r
ee
s
(
)
,
m
a
x
im
u
m
d
e
p
th
(
ma
x_
d
ep
t
h
)
,
a
n
d
th
e
n
u
m
b
er
o
f
f
ea
tu
r
es
(
)
,
u
s
ed
f
o
r
s
p
litt
in
g
.
T
h
e
v
ar
iab
le
is
th
e
h
y
p
er
p
ar
am
eter
g
r
id
th
at
d
ef
in
e
s
th
e
p
o
s
s
ib
le
co
m
b
in
atio
n
s
o
f
th
ese
p
ar
am
eter
s
.
T
h
e
v
ar
iab
le
(
t
r
ain
,
)
is
th
e
r
an
d
o
m
f
o
r
est
m
o
d
el
tr
ain
ed
o
n
d
iab
etes
tr
ai
n
in
g
d
ata
tr
ain
with
th
e
h
y
p
er
p
ar
a
m
eter
s
Θ
.
T
h
e
v
ar
iab
le
is
th
e
p
er
f
o
r
m
a
n
ce
m
etr
ic
(
e.
g
.
,
ac
cu
r
ac
y
,
p
r
ec
is
io
n
,
an
d
r
ec
all)
u
s
e
d
to
ev
al
u
ate
th
e
m
o
d
el'
s
ab
ilit
y
to
p
r
ed
ict
d
iab
etes.
T
h
e
v
ar
iab
le
tr
ain
is
th
e
ac
tu
al
lab
el
o
f
d
iab
etes
in
th
e
tr
ain
in
g
s
et.
T
h
e
v
ar
iab
le
Θ
∗
is
th
e
o
p
tim
al
s
et
o
f
h
y
p
er
p
ar
am
eter
s
th
at
m
a
x
im
izes th
e
p
er
f
o
r
m
an
ce
m
etr
ic
.
Alg
o
r
ith
m
2
.
Step
s
f
o
r
R
an
d
o
m
ized
S
ea
r
ch
C
V
to
o
p
tim
ize
h
y
p
er
p
a
r
am
eter
s
I
n
p
u
t:
Hy
p
er
p
ar
a
m
eter
g
r
id
(
H)
,
no
.
o
f
iter
atio
n
s
(
it
e
r
)
,
cr
o
s
s
-
v
alid
atio
n
f
o
l
d
s
(
K)
,
d
iab
etes
tr
ain
i
n
g
d
ata
(
tr
ain
)
,
d
iab
etes te
s
t d
ata
(
tes
t
)
,
n
u
m
b
er
o
f
tr
ee
s
/est
im
ato
r
s
(
T
)
,
n
u
m
b
e
r
o
f
f
ea
t
u
r
es (
m
)
Ou
tp
u
t:
Op
tim
ized
h
y
p
er
p
ar
a
m
eter
s
(
∗
)
,
tr
ain
ed
r
an
d
o
m
f
o
r
e
s
t
m
o
d
el
(
)
,
d
iab
etes
p
r
ed
ictio
n
s
(
ˆ
tes
t
)
,
p
er
f
o
r
m
an
ce
m
etr
ics (
e.
g
.
,
ac
c
u
r
ac
y
,
p
r
ec
is
io
n
,
an
d
r
ec
all)
.
1.
Def
in
e
h
y
p
e
r
p
ar
am
ete
r
g
r
id
:
d
ef
in
e
H,
in
clu
d
i
n
g
T
,
m
ax
_
d
ep
th
,
an
d
m
.
2.
I
n
itialize
R
an
d
o
m
ized
Sear
ch
C
V:
s
et
u
p
H,
ite
r
atio
n
s
it
e
r
,
an
d
K
-
f
o
ld
C
V.
3.
T
r
ain
m
o
d
els o
n
d
iab
etes d
ata:
f
it
R
an
d
o
m
ized
Sear
ch
C
V
u
s
in
g
d
iab
etes tr
ain
in
g
d
ata
t
r
ain
.
4.
Select
b
est h
y
p
er
p
ar
am
ete
r
s
: c
h
o
o
s
e
o
p
tim
al
∗
m
ax
im
izin
g
C
V
ac
cu
r
ac
y
f
o
r
class
if
icatio
n
.
5.
Fin
al
d
iab
etes p
r
ed
ictio
n
: o
p
tim
ized
∗
to
p
r
ed
ict
d
iab
etes o
u
tco
m
es o
n
test
d
ata.
3.
RE
SU
L
T
S AN
D
D
I
SCU
SS
I
O
N
3
.
1
.
M
o
del e
v
a
lua
t
i
o
n m
et
ri
cs
T
ab
le
2
s
h
o
ws
a
s
u
m
m
a
r
y
o
f
th
e
ad
o
p
te
d
ev
alu
atio
n
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etr
ic
s
,
th
eir
eq
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atio
n
s
,
a
n
d
th
ei
r
d
e
f
in
itio
n
in
d
iab
etes
p
r
ed
ictio
n
ter
m
s
.
E
v
a
lu
atio
n
is
a
cr
u
cial
s
tag
e
in
th
e
ML
p
r
o
ce
s
s
.
Pre
d
ictio
n
s
ar
e
m
ad
e
o
n
a
2
0
%
test
d
ataset
u
s
in
g
th
e
p
r
ev
io
u
s
ly
tr
ain
ed
f
r
am
ewo
r
k
.
T
h
is
s
tep
ass
ess
e
s
th
e
f
r
am
ewo
r
k
'
s
ab
ilit
y
to
g
en
er
alize
n
ew
d
ata
an
d
m
ea
s
u
r
es
its
ef
f
ec
tiv
en
ess
in
p
r
ac
tical
s
itu
atio
n
s
.
T
h
e
p
r
im
ar
y
o
b
jectiv
e
is
to
ev
alu
ate
th
e
ac
cu
r
ac
y
an
d
r
o
b
u
s
tn
ess
o
f
th
e
tr
ain
ed
f
r
am
ewo
r
k
wh
en
ap
p
lied
to
u
n
s
ee
n
d
ata
.
E
v
alu
atio
n
h
el
p
s
id
en
tify
p
o
ten
tial
is
s
u
es
lik
e
o
v
er
f
itti
n
g
o
r
u
n
d
e
r
f
itti
n
g
an
d
p
r
o
v
id
es
in
s
ig
h
ts
in
to
th
e
f
r
am
ewo
r
k
'
s
g
en
er
aliza
tio
n
ca
p
ab
ilit
ies.
T
o
ef
f
ec
tiv
ely
ass
ess
th
e
im
p
ac
t
o
f
th
e
alg
o
r
ith
m
,
it
is
es
s
en
tial
to
d
ef
in
e
s
p
ec
if
ic
p
er
f
o
r
m
an
ce
m
etr
ics
th
at
Evaluation Warning : The document was created with Spire.PDF for Python.
I
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ca
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m
ea
s
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r
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th
e
q
u
ality
o
f
a
class
if
icatio
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f
r
am
ewo
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k
[
4
]
.
T
h
e
m
o
d
el
ev
alu
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m
etr
ics
ar
e
ac
cu
r
ac
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,
p
r
ec
is
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,
r
ec
all,
F1
-
s
co
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e,
an
d
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OC
.
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h
e
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m
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n
ce
ev
a
lu
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i
m
ar
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v
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l
cu
latio
n
s
b
ased
o
n
th
e
co
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f
u
s
io
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m
atr
ix
[
2
]
.
A
co
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f
u
s
io
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atr
i
x
e
v
alu
ates
h
o
w
well
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clas
s
if
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f
r
am
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k
p
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ed
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d
iab
etic
an
d
n
o
n
-
d
ia
b
etic
p
atien
ts
as
f
o
llo
ws
[
2
]
,
[
4
]
.
A
tr
u
e
p
o
s
itiv
e
(
T
P)
s
h
o
ws
th
at
a
d
iab
etic
p
atien
t
is
co
r
r
ec
tly
p
r
ed
icted
as
d
iab
etic.
A
tr
u
e
n
eg
ativ
e
(
T
N)
s
h
o
ws
th
at
a
n
o
n
-
d
iab
etic
p
atien
t
i
s
co
r
r
ec
tl
y
p
r
ed
icted
as
n
o
n
-
d
iab
etic.
A
FN
s
h
o
ws
th
at
a
d
iab
etic
p
atien
t
is
in
co
r
r
ec
tly
p
r
ed
icted
as
n
o
n
-
d
ia
b
etic.
L
astl
y
,
a
f
alse
p
o
s
itiv
e
(
FP
)
in
d
icate
s
th
at
a
n
o
n
-
d
iab
etic
p
atien
t
is
in
co
r
r
ec
tly
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r
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icted
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d
iab
etic.
T
h
e
f
r
am
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d
ev
elo
p
m
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an
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[
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+
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P
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3
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2
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H
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o
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y
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ar
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th
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r
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k
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ar
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eter
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ato
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m
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,
wh
ic
h
s
ets
th
e
m
ax
im
u
m
d
ep
th
o
f
ea
ch
tr
ee
,
v
ar
ied
b
etwe
en
1
an
d
2
5
0
to
s
tr
ik
e
a
b
alan
ce
b
etwe
en
ca
p
tu
r
i
n
g
c
o
m
p
lex
p
atter
n
s
an
d
p
r
ev
e
n
t
in
g
o
v
er
f
itti
n
g
.
Ad
d
itio
n
ally
,
we
ad
ju
s
ted
th
e
m
in
_
s
am
p
les_
s
p
lit
an
d
m
in
_
s
am
p
les_
leaf
p
ar
am
eter
s
,
wi
th
v
alu
es
r
a
n
g
in
g
f
r
o
m
2
t
o
5
a
n
d
1
to
3
,
r
esp
ec
tiv
ely
.
T
h
ese
p
ar
am
eter
s
co
n
tr
o
l
th
e
m
in
im
u
m
n
u
m
b
er
o
f
s
am
p
les
r
e
q
u
ir
ed
to
s
p
lit
a
n
o
d
e
an
d
to
b
e
p
r
es
en
t a
t a
leaf
n
o
d
e,
th
e
r
eb
y
in
f
lu
en
cin
g
th
e
f
r
a
m
ewo
r
k
'
s
co
m
p
lex
ity
a
n
d
g
e
n
er
aliza
tio
n
ab
ilit
y
.
3
.
3
.
B
est
f
ra
m
ewo
r
k
pa
ra
met
er
s
T
h
e
h
y
p
e
r
p
ar
am
eter
s
ea
r
ch
i
d
en
tifie
d
an
ef
f
ec
tiv
e
c
o
m
b
i
n
atio
n
th
at
s
ig
n
if
ican
tly
b
o
o
s
ted
m
o
d
el
p
er
f
o
r
m
an
ce
.
A
m
a
x
_
d
e
p
th
o
f
1
8
8
a
llo
we
d
tr
ee
s
to
ca
p
tu
r
e
co
m
p
lex
p
atter
n
s
,
wh
ile
m
ax
_
f
ea
tu
r
es
s
et
to
'
au
to
'
en
ab
led
th
e
u
s
e
o
f
all
av
ailab
le
f
ea
tu
r
es
d
u
r
in
g
s
p
lits
.
T
h
e
m
in
_
s
am
p
les_
leaf
was
s
et
to
1
,
allo
win
g
h
ig
h
ly
d
etailed
tr
ee
s
,
an
d
t
h
e
m
in
_
s
am
p
les_
s
p
lit
s
et
to
3
h
elp
ed
p
r
ev
en
t
o
v
er
f
itti
n
g
b
y
r
eq
u
i
r
in
g
at
least
th
r
ee
s
am
p
les
to
s
p
lit
a
n
o
d
e.
Ad
d
itio
n
ally
,
n
_
esti
m
ato
r
s
was
s
et
to
2
2
,
p
r
o
v
id
in
g
a
co
m
p
ac
t
y
e
t
s
tr
o
n
g
en
s
em
b
le.
T
h
ese
o
p
tim
ized
s
ettin
g
s
r
esu
lted
in
a
b
est
cr
o
s
s
-
v
alid
atio
n
s
co
r
e
o
f
0
.
9
7
1
9
,
in
d
icatin
g
s
tr
o
n
g
g
en
er
aliza
tio
n
to
u
n
s
ee
n
d
ata.
3
.
4
.
P
r
o
po
s
ed
f
ra
m
ewo
r
k
re
s
ults
-
no
co
m
pa
riso
n
T
h
e
R
an
d
o
m
ized
Sear
ch
C
V
was
s
et
u
p
to
as
s
es
s
ten
d
if
f
er
en
t
co
m
b
in
atio
n
s
o
f
p
a
r
am
eter
s
th
r
o
u
g
h
10
-
f
o
l
d
c
r
o
s
s
-
v
alid
atio
n
[
2
4
]
,
[
2
5
]
,
r
esu
ltin
g
in
a
t
o
tal
o
f
1
0
0
f
r
a
m
ewo
r
k
f
its
.
Af
te
r
th
is
e
x
ten
s
iv
e
s
ea
r
ch
,
th
e
f
r
am
ewo
r
k
was
test
ed
o
n
a
s
ep
ar
ate
test
s
et.
Fig
u
r
e
5
s
h
o
ws
th
e
r
esu
lts
o
f
t
h
e
p
r
o
p
o
s
ed
f
r
am
ew
o
r
k
.
T
h
e
r
esu
lts
o
f
th
e
p
r
o
p
o
s
ed
R
an
d
o
m
DI
P
f
r
am
ewo
r
k
d
em
o
n
s
tr
ate
its
ex
ce
p
tio
n
al
ca
p
ab
ilit
y
in
p
r
ed
ictin
g
d
iab
etes,
with
n
o
tab
le
tr
en
d
s
an
d
p
atter
n
s
th
at
h
ig
h
lig
h
t
its
ef
f
ec
t
iv
en
ess
.
T
h
e
ac
cu
r
ac
y
o
f
9
9
.
4
%
in
d
icate
s
th
at
R
an
d
o
m
DI
P
is
h
ig
h
ly
r
eliab
le
in
co
r
r
ec
tly
id
en
tify
in
g
b
o
th
d
iab
etic
an
d
n
o
n
-
d
iab
etic
in
d
iv
id
u
als.
T
h
e
h
ig
h
ac
cu
r
ac
y
s
u
g
g
ests
th
at
th
e
m
o
d
el
h
as
lear
n
ed
to
ca
p
t
u
r
e
th
e
u
n
d
er
ly
i
n
g
p
atter
n
s
in
th
e
d
ata
,
en
s
u
r
in
g
m
in
im
al
m
is
class
if
icatio
n
,
wh
ich
is
cr
itical
in
m
ed
ical
d
iag
n
o
s
is
to
av
o
id
FN
s
o
r
FP
s
.
T
h
e
R
OC
A
UC
s
co
r
e
o
f
9
9
.
6
%
s
u
g
g
ests
th
at
R
an
d
o
m
DI
P
is
h
ig
h
ly
p
r
o
f
icien
t
in
d
is
tin
g
u
is
h
in
g
b
etwe
en
d
iab
etic
an
d
n
o
n
-
d
iab
etic
p
atien
ts
.
Evaluation Warning : The document was created with Spire.PDF for Python.
I
n
t J
Ad
v
Ap
p
l Sci
I
SS
N:
2252
-
8
8
1
4
Op
timiz
in
g
d
ia
b
etes p
r
ed
ictio
n
u
s
in
g
ma
c
h
in
e
lea
r
n
in
g
:
a
r
a
n
d
o
m
fo
r
est a
p
p
r
o
a
ch
(
A
o
n
e
Ma
en
g
e)
463
T
h
e
n
ea
r
-
p
er
f
ec
t
v
alu
e
r
ef
lec
ts
th
e
m
o
d
el'
s
ab
ili
ty
to
m
ain
tain
h
ig
h
p
er
f
o
r
m
a
n
ce
ev
en
wh
en
ad
ju
s
tin
g
th
e
d
ec
is
io
n
th
r
esh
o
ld
,
en
s
u
r
i
n
g
t
h
at
th
e
p
r
ed
ictio
n
s
y
s
tem
d
o
e
s
n
o
t
m
is
s
p
atien
ts
with
d
iab
e
tes,
a
cr
u
cial
asp
ec
t
in
ea
r
ly
d
iag
n
o
s
is
an
d
tr
ea
tm
e
n
t.
A
p
r
ec
is
io
n
o
f
9
7
.
8
%
m
ea
n
s
th
at
wh
en
R
an
d
o
m
DI
P
p
r
e
d
icts
a
p
atien
t
h
as
d
iab
etes,
i
t
is
h
ig
h
ly
lik
ely
to
b
e
co
r
r
ec
t.
T
h
is
is
cr
u
cial
in
h
ea
lth
ca
r
e
b
ec
au
s
e
h
ig
h
p
r
ec
is
io
n
r
ed
u
ce
s
th
e
o
cc
u
r
r
e
n
ce
o
f
FP
s
,
p
r
ev
en
tin
g
p
atien
ts
f
r
o
m
u
n
d
er
g
o
in
g
u
n
n
ec
ess
ar
y
m
ed
ical
tr
ea
tm
en
ts
o
r
in
ter
v
en
tio
n
s
.
T
h
e
p
e
r
f
ec
t
r
ec
all
s
co
r
e
(
1
0
0
%)
i
n
d
icate
s
th
at
th
e
m
o
d
el
id
e
n
tifie
s
all
ac
tu
al
d
iab
etic
p
atien
ts
with
o
u
t
m
i
s
s
in
g
an
y
.
T
h
is
is
esp
ec
ially
im
p
o
r
tan
t
in
d
iab
et
es
p
r
ed
ictio
n
,
as
m
is
s
in
g
a
d
iab
etic
p
atien
t
co
u
ld
lea
d
to
d
el
ay
ed
d
ia
g
n
o
s
is
an
d
tr
ea
tm
en
t,
p
o
ten
tially
r
esu
ltin
g
in
s
ev
er
e
h
ea
lth
co
m
p
licatio
n
s
.
T
h
e
m
o
d
el'
s
ab
ilit
y
to
ac
h
iev
e
p
er
f
ec
t
r
ec
all
in
d
icate
s
its
ef
f
ec
tiv
en
ess
in
ca
tch
in
g
ev
e
r
y
p
o
s
s
ib
le
d
iab
etes
ca
s
e,
en
s
u
r
in
g
ea
r
ly
in
te
r
v
en
tio
n
.
F1
-
s
co
r
e
(
9
8
.
9
%)
.
T
h
e
F1
-
s
co
r
e
with
a
v
alu
e
o
f
9
8
.
9
%
r
ef
lects
a
well
-
b
alan
ce
d
m
o
d
el.
T
h
is
h
ig
h
F1
-
s
co
r
e
d
em
o
n
s
tr
ates
th
at
R
an
d
o
m
D
I
P
n
o
t
o
n
ly
p
er
f
o
r
m
s
well
in
id
en
tify
in
g
d
iab
etic
ca
s
es
b
u
t
also
m
ain
tain
s
a
s
tr
o
n
g
ab
ilit
y
to
a
v
o
id
FP
s
,
m
a
k
in
g
it a
n
i
d
ea
l m
o
d
el
f
o
r
p
r
ac
tical
d
iab
etes p
r
ed
ictio
n
.
Fig
u
r
e
5
.
Pro
p
o
s
ed
f
r
am
ewo
r
k
r
esu
lts
3
.
5
.
P
r
o
po
s
ed
f
ra
m
ewo
r
k
re
s
ults
–
co
m
pa
riso
n wit
h r
ela
t
ed
f
ra
m
ewo
r
k
s
T
h
e
p
r
o
p
o
s
ed
f
r
am
ewo
r
k
is
n
o
w
co
m
p
a
r
ed
with
r
elate
d
wo
r
k
s
f
r
o
m
th
e
r
ev
iewe
d
.
T
h
e
c
o
m
p
ar
is
o
n
f
r
am
ewo
r
k
s
ar
e
Atif
et
a
l.
[
4
]
,
C
h
o
u
et
a
l.
[
1
3
]
,
A
n
b
an
an
th
en
et
a
l.
[
1
6
]
s
h
o
r
ten
e
d
as
An
b
an
,
an
d
o
u
r
p
r
o
p
o
s
ed
R
an
d
o
m
DI
P
.
W
e
co
m
p
ar
ed
o
u
r
f
r
am
ewo
r
k
with
ex
is
tin
g
f
r
am
ewo
r
k
s
f
o
r
p
er
f
o
r
m
an
ce
in
ter
m
s
o
f
th
e
ev
alu
atio
n
m
etr
ics
o
f
ac
cu
r
ac
y
,
R
OC
AUC,
p
r
ec
is
io
n
,
r
ec
all,
an
d
F1
-
s
co
r
e
.
W
e
d
id
th
is
f
o
r
a
f
ai
r
co
m
p
ar
is
o
n
,
as
o
u
r
f
r
am
ewo
r
k
u
s
es
th
e
s
am
e
m
etr
ics.
Ou
r
co
m
p
ar
is
o
n
r
esu
lts
clea
r
ly
s
h
o
w
th
at
th
e
p
r
o
p
o
s
ed
r
an
d
o
m
f
o
r
est f
r
am
ewo
r
k
o
u
tp
er
f
o
r
m
s
o
th
er
m
eth
o
d
s
in
all
e
v
alu
ated
m
etr
ics.
Fig
u
r
e
6
s
h
o
ws
th
e
a
cc
u
r
ac
y
m
et
r
i
c
o
f
a
ll
t
h
e
f
r
a
m
ew
o
r
k
s
.
T
h
e
f
ig
u
r
e
h
i
g
h
li
g
h
ts
t
h
a
t
t
h
e
p
r
o
p
o
s
e
d
R
an
d
o
m
D
I
P
f
r
am
ew
o
r
k
s
ig
n
if
i
ca
n
tl
y
o
u
t
p
e
r
f
o
r
m
s
all
o
t
h
e
r
f
r
a
m
e
wo
r
k
s
wi
th
a
n
ac
c
u
r
a
cy
o
f
9
9
.
4
%
.
T
h
e
p
r
o
p
o
s
e
d
R
a
n
d
o
m
D
I
P
o
u
t
p
e
r
f
o
r
m
s
C
h
o
u
et
a
l.
[
1
3
]
(
9
5
.
3
%)
b
y
4
.
3
0
%,
Atif
et
a
l.
[
4
]
(
9
7
.
2
%)
b
y
2
.
2
6
%
,
a
n
d
An
b
an
an
th
e
n
et
a
l.
[
1
6
]
(
9
8
.
5
%)
b
y
0
.
9
1
%.
T
h
e
r
e
aso
n
f
o
r
t
h
e
h
i
g
h
a
cc
u
r
ac
y
o
f
t
h
e
p
r
o
p
o
s
e
d
f
r
a
m
e
wo
r
k
co
m
p
a
r
e
d
t
o
o
t
h
er
s
is
d
u
e
t
o
(
1
)
e
f
f
ec
t
iv
e
h
y
p
er
p
ar
am
et
er
tu
n
i
n
g
th
r
o
u
g
h
R
an
d
o
m
iz
ed
S
ea
r
c
h
C
V
,
w
h
i
ch
o
p
ti
m
iz
es
t
h
e
r
a
n
d
o
m
f
o
r
est
m
o
d
el'
s
p
ar
a
m
et
er
s
,
a
n
d
(
2
)
r
o
b
u
s
t
f
ea
t
u
r
e
s
e
le
cti
o
n
t
h
at
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im
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ates
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