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t
a
b
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l
is
m
c
a
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b
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r
e
g
u
l
at
ed
u
s
i
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p
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e
Evaluation Warning : The document was created with Spire.PDF for Python.
I
SS
N
:
1
6
9
3
-
6
9
3
0
TEL
KOM
NI
KA
T
elec
o
m
m
u
n
C
o
m
p
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t E
l
C
o
n
tr
o
l
,
Vo
l.
23
,
No
.
5
,
Octo
b
e
r
20
25
:
1
3
8
5
-
1
3
9
4
1386
a
d
a
p
t
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v
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c
o
n
t
r
o
l
w
it
h
t
h
e
c
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n
d
i
t
i
o
n
t
h
at
t
h
i
s
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y
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t
e
m
i
s
a
l
m
o
s
t
s
t
r
ic
t
l
y
p
o
s
i
ti
v
e
r
e
al
(
ASPR
)
[
1
4
]
.
Ka
r
i
m
a
a
n
d
M
o
u
r
a
d
[1
5
]
a
d
o
p
t
s
t
h
e
p
r
i
n
c
ip
l
e
o
f
s
a
t
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t
h
a
t
m
e
a
n
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h
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a
m
o
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l
i
n
d
o
n
o
t
t
ak
e
a
h
i
g
h
v
a
l
u
e
.
T
h
e
r
e
s
u
l
ts
s
h
o
w
s
t
h
a
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e
i
r
c
o
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g
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o
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u
l
t
s
a
n
d
o
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t
h
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e
g
l
u
c
o
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e
is
r
e
g
u
l
a
t
e
d
w
it
h
i
n
a
n
a
c
c
e
p
t
a
b
l
e
t
i
m
e
.
T
h
e
f
u
z
z
y
l
o
g
i
c
u
s
i
n
g
t
h
e
m
a
m
d
a
n
i
c
o
n
c
e
p
t
i
s
u
s
e
d
i
n
[
16
]
w
h
e
r
e
t
h
e
c
o
n
t
r
o
l
l
e
r
i
n
a
p
p
li
e
d
f
o
r
t
h
r
e
e
p
a
t
i
e
n
ts
a
n
d
t
h
e
a
u
t
h
o
r
s
c
l
a
i
m
t
h
a
t
t
h
e
c
o
n
t
r
o
l
l
e
r
g
i
v
e
a
g
o
o
d
r
e
s
u
l
t
i
n
t
h
e
s
e
n
s
e
t
h
a
t
t
h
e
g
l
u
c
o
s
e
i
n
r
e
g
u
l
a
t
e
d
a
t
a
n
a
t
u
r
al
v
a
l
u
es
.
T
h
e
m
ain
o
b
jectiv
e
o
f
th
is
s
tu
d
y
is
th
e
r
ea
lizatio
n
o
f
a
n
ar
ti
f
icial
p
an
cr
ea
s
ca
p
ab
le
o
f
p
r
o
v
id
in
g
t
h
e
ap
p
r
o
p
r
iate
d
o
s
e
o
f
in
s
ilin
e
in
d
ep
en
d
en
tly
o
f
t
h
e
p
atien
t,
s
o
th
e
latter
ca
n
le
ad
h
is
life
i
n
an
a
d
eq
u
ate
way
.
T
h
is
ar
tific
ial
p
an
cr
ea
s
is
eq
u
ip
p
ed
with
alar
m
s
in
ca
s
e
o
f
h
y
p
er
g
ly
ce
m
ia
o
r
h
y
p
o
g
ly
ce
m
ia
.
T
h
e
d
escr
ip
tio
n
o
f
th
e
g
lu
co
s
e
in
s
u
lin
m
etab
o
lis
m
is
d
e
s
cr
ib
ed
in
[
17
]
.
L
ew
is
et
a
l
.
[
18
]
g
iv
es
two
r
eg
u
la
tio
n
m
eth
o
d
ca
lled
th
e
d
ir
ec
t
a
n
d
in
d
ir
ec
t
ac
tio
n
s
.
T
h
e
p
r
o
p
o
r
tio
n
al
-
i
n
teg
r
al
-
d
er
iv
ativ
e
(
PID
)
co
n
tr
o
l
[
19
]
i
s
u
s
ed
in
g
lu
co
s
e
in
s
u
lin
r
eg
u
latio
n
wh
er
e
th
e
p
r
o
p
o
r
tio
n
al,
in
teg
r
al
an
d
d
er
iv
ativ
e
ar
e
ch
an
g
ed
in
o
r
d
er
t
o
f
o
r
ce
th
e
g
lu
c
o
s
e
co
n
ce
n
tr
atio
n
to
b
e
in
th
e
ac
ce
p
tab
le
v
alu
es.
R
ih
an
an
d
Ud
h
ay
ak
u
m
ar
[2
0
]
u
s
es
th
e
f
r
ac
tio
n
al
o
r
d
e
r
with
tim
e
d
elay
to
r
eg
u
late
th
e
g
lu
c
o
s
e,
t
h
e
f
r
ac
tio
n
o
r
d
er
is
a
co
n
ce
p
t w
h
er
e
o
n
e
s
u
p
p
o
s
e
th
et
th
e
o
r
d
er
o
f
th
e
s
y
s
tem
is
f
r
ac
tio
n
al
wh
er
e
th
e
s
y
s
tem
o
r
d
er
is
f
r
ac
tio
n
al
w
h
ich
is
a
m
o
r
e
g
en
er
al
n
o
tio
n
th
a
n
a
s
y
s
tem
with
in
teg
er
o
r
d
er
.
T
h
e
p
a
p
er
is
o
r
g
an
ize
d
as
f
o
llo
ws.
I
n
s
ec
tio
n
2
,
o
n
e
g
i
v
e
th
e
i
n
p
u
t
o
u
tp
u
t
lin
ea
r
iza
tio
n
.
T
h
e
B
er
g
m
an
m
in
im
al
m
o
d
el
is
g
iv
en
in
s
e
ctio
n
3
.
I
n
s
e
ctio
n
4
o
n
e
ap
p
ly
th
e
in
p
u
t
o
u
t
p
u
t
(
I
/
O
)
lin
ea
r
izatio
n
to
r
eg
u
late
th
e
g
lu
co
s
e
lev
el.
Simu
latio
n
s
r
esu
lts
ar
e
g
iv
en
in
s
ec
tio
n
5
an
d
we
en
d
th
is
p
ap
er
with
a
co
n
clu
s
io
n
in
s
ec
tio
n
6
.
2.
I
NP
UT
O
U
T
P
UT
L
I
N
E
AR
I
Z
AT
I
O
N
I
n
p
u
t
-
o
u
tp
u
t
lin
ea
r
izatio
n
is
a
r
ec
en
t
co
n
tr
o
l
tec
h
n
iq
u
e,
it
co
n
s
is
ts
o
f
lin
ea
r
izin
g
a
n
o
n
-
lin
e
ar
s
y
s
tem
u
s
in
g
a
s
tate
o
r
o
u
t
p
u
t
f
ee
d
b
a
ck
an
d
u
s
in
g
a
n
ew
co
m
m
a
n
d
.
T
h
is
tech
n
iq
u
e
m
ak
es
it
p
o
s
s
ib
le
to
ap
p
ly
well
-
m
k
n
o
wn
lin
ea
r
co
n
tr
o
ls
to
co
m
p
licated
an
d
n
o
n
-
lin
ea
r
s
y
s
tem
s
.
L
et’
s
tak
e
th
e
n
o
n
-
lin
ea
r
s
y
s
tem
[
2
1
]
.
{
.
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+
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1
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:
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(
ℎ
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with
(
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e
(
n
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-
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d
e
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:
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−
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(
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(
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0
An
d
th
e
n
th
d
er
iv
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is
g
iv
en
b
y
:
Evaluation Warning : The document was created with Spire.PDF for Python.
T
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L
KOM
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T
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m
m
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Mer
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I
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is
well
k
n
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w
th
at
th
is
f
o
r
m
is
s
u
itab
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f
o
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d
t
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ac
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.
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n
ce
th
e
co
m
m
a
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n
th
esized
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ac
tu
al
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m
m
an
d
is
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y
:
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with
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0
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I
n
t
h
i
s
s
e
c
t
i
o
n
,
o
n
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a
p
p
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h
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I
/
O
l
i
n
e
a
r
i
z
a
ti
o
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o
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g
u
l
a
t
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th
e
g
l
u
c
o
s
e
f
o
r
an
i
l
l
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ess
p
e
r
s
o
n
.
T
h
i
s
is
a
c
h
i
e
v
e
d
b
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s
e
a
r
c
h
i
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a
m
o
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f
i
n
s
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b
e
i
n
j
e
c
t
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d
i
n
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r
d
e
r
t
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r
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g
u
l
a
t
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t
h
e
g
l
u
c
o
s
e
a
t i
t
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s
b
a
s
al
v
a
l
u
e
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h
a
t
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a
n
s
t
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o
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a
l
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e
a
n
d
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n
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b
e
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i
n
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y
t
h
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m
o
d
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i
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at
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l
u
c
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l
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tab
o
l
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s
m
.
Z
a
k
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a
n
d
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z
g
o
l
i
[2
2
]
,
t
h
e
au
th
o
r
s
u
s
e
d
a
s
t
a
te
f
e
e
d
b
a
c
k
c
o
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e
r
t
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u
l
a
t
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h
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g
l
u
c
o
s
e
a
t
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s
b
a
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v
a
l
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r
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i
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f
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t
i
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te
r
m
s
o
f
r
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p
o
n
s
e
t
i
m
e
.
3.
B
E
RG
M
AN
M
I
N
I
M
AL
M
O
DE
L
T
h
er
e
ar
e
m
an
y
m
o
d
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t
D
x
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x
p
t
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p
x
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t
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x
x
G
x
p
x
e
b
b
+
−
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+
+
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+
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So
,
(
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x
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t
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x
p
x
x
p
t
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x
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G
x
p
x
e
b
b
+
−
−
+
−
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+
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+
−
=
T
h
at
m
ea
n
s
:
(
)
(
)
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(
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(
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..
1
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3
3
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1
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.
.
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t
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x
p
x
p
x
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p
t
D
x
x
G
x
p
x
e
b
b
+
−
−
+
−
+
−
+
+
+
+
+
−
+
−
=
So
,
(
)
(
)
(
)
)
(
)
(
)
(
)
(
)
(
)
(
)
(
..
1
1
3
4
3
.
2
1
3
3
2
2
2
2
1
1
.
1
2
1
2
1
1
2
1
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2
.
.
.
.
t
D
x
t
u
I
x
p
p
t
D
x
p
I
x
p
x
p
x
p
x
x
p
x
x
p
t
D
x
x
G
x
p
x
e
b
b
b
+
+
−
−
−
+
−
−
−
+
+
+
+
+
+
−
+
−
=
T
h
e
th
ir
d
d
er
iv
ativ
e
ca
n
b
e
wr
itten
as
:
(
)
(
)
(
)
)
(
)
(
)
(
)
(
)
(
)
(
)
(
)
(
)
(
)
(
..
1
3
1
1
3
4
3
2
1
3
3
2
2
2
2
1
1
2
1
1
1
2
1
2
1
1
2
1
1
3
3
2
2
.
.
.
t
D
x
t
u
p
x
I
x
p
p
t
D
x
p
I
x
p
x
p
x
p
t
D
x
x
G
x
p
x
p
x
x
p
t
D
x
x
G
x
p
I
x
p
x
p
e
b
b
b
b
b
+
−
−
+
−
−
−
+
+
+
−
−
−
+
+
+
+
−
+
−
−
+
−
=
•
(
1
4
)
I
n
th
e
f
o
r
m
:
.
.
.
=
−
(
)
1
(
1
5
)
W
h
er
e
:
(
)
(
)
(
)
)
(
)
(
)
(
)
(
)
(
)
(
)
(
)
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)
(
..
1
1
3
4
3
2
1
3
3
2
2
2
2
1
1
2
1
1
1
2
1
2
1
1
2
1
1
3
3
2
2
t
D
x
I
x
p
p
t
D
x
p
I
x
p
x
p
x
p
t
D
x
x
G
x
p
x
p
x
x
p
t
D
x
x
G
x
p
I
x
p
x
p
b
b
b
b
b
+
−
+
−
−
−
+
+
+
−
−
−
+
+
+
−
+
−
−
+
−
=
•
Le
t
’
s
tak
e
th
e
Hu
r
witz
p
o
l
y
n
o
m
ial
.
Evaluation Warning : The document was created with Spire.PDF for Python.
T
E
L
KOM
NI
KA
T
elec
o
m
m
u
n
C
o
m
p
u
t E
l Co
n
tr
o
l
R
eg
u
la
tio
n
o
f g
lu
c
o
s
e
in
s
u
lin
meta
b
o
lis
m
u
s
in
g
feed
b
a
ck
lin
ea
r
iz
a
tio
n
(
Mer
iem
S
a
ma
i)
1391
3
+
2
2
+
1
+
0
(
1
6
)
So
,
th
e
d
if
f
e
r
en
tial e
q
u
atio
n
:
.
.
.
+
2
.
.
+
1
.
+
0
=
0
(
1
7
)
I
m
p
lies
th
at
th
e
er
r
o
r
)
(
t
e
g
o
es to
z
er
o
an
d
th
en
(
)
g
o
es to
.
Fro
m
th
e
later
eq
u
atio
n
,
o
n
e
h
av
e
:
.
.
.
=
−
2
.
.
−
1
.
−
0
=
−
(
)
1
(
1
8
)
An
d
th
en
th
e
co
m
m
a
n
d
u
(
t
)
is
g
iv
en
b
y
:
1
3
0
.
1
..
2
)
(
x
p
e
e
e
t
u
+
+
+
=
(
1
9
)
W
ith
(
)
≠
0
.
L
et
’
s
tak
e
1
,
2
an
d
3
z
as th
e
p
o
les in
th
e
f
ee
d
b
ac
k
lo
o
p
,
s
o
th
e
c
h
ar
ac
ter
is
tic
p
o
ly
n
o
m
ial
is
g
iv
en
b
y
:
+
+
+
=
−
+
+
+
−
−
−
+
=
−
+
−
−
=
−
−
−
=
s
s
s
z
z
z
z
z
z
z
z
z
s
z
z
z
s
s
z
s
z
z
s
z
s
z
s
z
s
z
s
z
s
s
P
1
2
2
3
3
2
1
3
1
2
1
3
2
3
2
1
2
3
3
2
1
2
1
2
3
2
1
)
(
)
(
)
)(
(
)
)(
)(
(
)
(
(
2
0
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S
o
,
3
2
1
2
3
1
2
1
3
2
1
3
2
1
0
z
z
z
z
z
z
z
z
z
z
z
z
−
−
−
=
+
+
=
−
=
(
2
1
)
5.
SI
M
UL
A
T
I
O
N
In
th
e
s
im
u
latio
n
,
it
is
r
eq
u
ir
ed
th
at
th
e
g
lu
c
o
s
e
co
n
ce
n
tr
atio
n
tr
ac
k
s
it
’
s
b
asal
r
ef
er
en
ce
G
b
=8
0
mg
/d
l
b
y
in
jectin
g
th
e
s
u
f
f
icien
t
am
o
u
n
t
o
f
i
n
s
u
lin
.
On
e
s
u
p
p
o
s
e
t
h
at
at
t
=2
5
0
m
i
n
a
p
e
r
tu
r
b
atio
n
is
ad
d
ed
r
ep
r
esen
ted
b
y
an
in
ta
k
e
o
f
ca
r
b
o
h
y
d
r
ates
o
f
th
e
f
o
r
m
(
)
=
(
−
)
,
>
0
.
T
h
e
s
im
u
latio
n
h
as
b
ee
n
d
o
n
e
o
v
er
5
0
0
m
in
.
T
h
e
in
itial
co
n
d
itio
n
s
ar
e
g
iv
en
b
y
1
=
0
;
2
=
0
.
025
;
3
=
0
.
00013
;
G
b
=8
0
m
g
/d
l
;
I
b
=7
μ
U/m
l
.
T
h
e
s
im
u
latio
n
is
d
o
n
e
o
v
er
5
0
0
m
in
.
An
d
th
e
r
o
o
ts
in
f
ee
d
b
ac
k
lo
o
p
ar
e
g
i
v
en
by
1
=
−
0
.
1
;
2
=
−
0
.
2
;
3
=
−
0
.
3
.
Fig
u
r
e
2
s
h
o
ws
th
e
ev
o
lu
tio
n
o
f
th
e
g
lu
co
s
e
c
o
n
ce
n
tr
ati
o
n
o
f
a
p
atien
t
an
d
o
n
e
s
ee
th
at
th
e
co
n
tr
o
ller
is
ab
le
to
lead
th
e
g
lu
co
s
e
to
it
’
s
n
o
r
m
al
v
alu
e
th
at
m
ea
n
s
G
b
=8
0
mg
/d
l
af
ter
ab
o
u
t
1
0
0
m
in
an
d
ju
s
t
th
e
o
cc
u
r
r
e
n
ce
o
f
th
e
p
er
tu
r
b
atio
n
,
le
g
lu
c
o
s
e
in
cr
ea
s
e
an
d
r
et
u
r
n
to
it
’
s
b
asal
v
alu
e
a
f
ter
7
5
m
in
.
F
i
g
u
r
e
3
s
h
o
w
s
t
h
e
e
v
o
l
u
t
i
o
n
o
f
t
h
e
i
n
s
u
l
i
n
w
h
ic
h
i
n
c
r
e
a
s
e
i
f
o
n
e
h
a
v
e
a
b
i
g
am
o
n
g
o
f
g
l
u
c
o
s
e
a
n
d
r
e
t
u
r
n
t
o
it
’
s
b
as
a
l
v
al
u
e
o
n
c
e
t
h
e
g
l
u
c
o
s
e
is
i
n
i
t
’
s
b
as
a
l
v
a
l
u
e
.
F
i
g
u
r
e
4
s
h
o
w
s
c
o
n
t
r
o
l
le
d
i
n
p
u
t
w
h
i
c
h
a
l
s
o
i
n
c
r
e
as
e
i
f
t
h
e
am
o
u
n
t
o
f
g
l
u
c
o
s
e
i
s
h
i
g
h
e
r
a
n
d
s
e
t
t
le
t
o
i
t
’
s
b
as
a
l
v
a
l
u
e
i
f
t
h
e
g
l
u
c
o
s
e
r
e
a
c
h
e
d
it
’
s
n
o
r
m
a
l
v
a
l
u
e
t
h
a
t
m
e
a
n
s
G
b
=
80
m
g
/
d
l
.
Fig
u
r
e
2
.
Glu
c
o
s
e
co
n
ce
n
tr
ati
o
n
f
o
r
a
p
atien
t
p
er
s
o
n
Fig
u
r
e
3
.
C
o
n
ce
n
tr
atio
n
o
f
in
s
u
lin
in
th
e
b
lo
o
d
Evaluation Warning : The document was created with Spire.PDF for Python.
I
SS
N
:
1
6
9
3
-
6
9
3
0
TEL
KOM
NI
KA
T
elec
o
m
m
u
n
C
o
m
p
u
t E
l
C
o
n
tr
o
l
,
Vo
l.
23
,
No
.
5
,
Octo
b
e
r
20
25
:
1
3
8
5
-
1
3
9
4
1392
Fig
u
r
e
4
.
C
o
m
m
a
n
d
(
i
n
s
u
lin
i
n
jectio
n
)
to
th
e
b
lo
o
d
g
lu
c
o
s
e
in
s
u
lin
s
y
s
tem
6.
CO
NCLU
SI
O
N
T
h
is
p
ap
er
p
r
esen
ts
at
f
ir
s
t
th
e
ad
ap
tiv
e
co
m
m
an
d
wh
ich
will
b
e
ap
p
lied
f
o
r
a
p
er
tu
r
b
ed
s
y
s
tem
.
T
h
e
L
y
ap
u
n
o
v
th
eo
r
y
h
as
b
ee
n
ad
d
r
ess
ed
in
o
r
d
er
th
e
ac
h
iev
e
a
r
o
b
u
s
t
co
m
m
an
d
ag
ain
s
t
th
e
u
n
ce
r
tain
ty
wh
ich
is
in
h
er
en
t
in
all
r
ea
l
s
y
s
tem
.
T
h
e
ad
a
p
tiv
e
c
o
m
m
an
d
h
as
b
ee
n
a
p
p
lied
to
c
o
n
tr
o
l
th
e
co
n
ce
n
tr
atio
n
o
f
th
e
g
lu
co
s
e
o
f
a
p
atien
t p
er
s
o
n
.
T
h
e
s
im
u
latio
n
r
esu
lts
co
n
f
ir
m
t
h
e
r
o
b
u
s
tn
ess
o
f
th
e
d
e
v
elo
p
e
d
co
n
tr
o
ller
.
F
UNDING
I
NF
O
R
M
A
T
I
O
N
Au
th
o
r
s
s
tate
n
o
f
u
n
d
in
g
in
v
o
lv
ed
.
AUTHO
R
CO
NT
RI
B
UT
I
O
NS ST
A
T
E
M
E
N
T
T
h
is
jo
u
r
n
al
u
s
es
th
e
C
o
n
tr
ib
u
to
r
R
o
les
T
ax
o
n
o
m
y
(
C
R
ed
iT)
to
r
ec
o
g
n
ize
in
d
iv
id
u
al
au
th
o
r
co
n
tr
ib
u
tio
n
s
,
r
ed
u
ce
au
th
o
r
s
h
ip
d
is
p
u
tes,
an
d
f
ac
ilit
ate
co
llab
o
r
atio
n
.
Na
m
e
o
f
Aut
ho
r
C
M
So
Va
Fo
I
R
D
O
E
Vi
Su
P
Fu
Me
r
iem
Sam
ai
✓
✓
✓
✓
✓
✓
✓
✓
✓
✓
✓
✓
Gh
e
d
jati K
elto
u
m
✓
✓
✓
✓
✓
✓
✓
✓
Ab
d
d
elaz
iz
Mo
u
r
ad
✓
✓
✓
✓
✓
✓
✓
✓
C
:
C
o
n
c
e
p
t
u
a
l
i
z
a
t
i
o
n
M
:
M
e
t
h
o
d
o
l
o
g
y
So
:
So
f
t
w
a
r
e
Va
:
Va
l
i
d
a
t
i
o
n
Fo
:
Fo
r
mal
a
n
a
l
y
s
i
s
I
:
I
n
v
e
s
t
i
g
a
t
i
o
n
R
:
R
e
so
u
r
c
e
s
D
:
D
a
t
a
C
u
r
a
t
i
o
n
O
:
W
r
i
t
i
n
g
-
O
r
i
g
i
n
a
l
D
r
a
f
t
E
:
W
r
i
t
i
n
g
-
R
e
v
i
e
w
&
E
d
i
t
i
n
g
Vi
:
Vi
su
a
l
i
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.
Evaluation Warning : The document was created with Spire.PDF for Python.